Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II.

Cingolani, Francesca; Casasampere, Mireia; Sanllehí, Pol; Casas, Josefina; Bujons, Jordi; Fabrias, Gemma

Cingolani, Francesca; Casasampere, Mireia; Sanllehí, Pol; Casas, Josefina; Bujons, Jordi; Fabrias, Gemma.

Afiliación

Cingolani F; Research Unit on BioActive Molecules (RUBAM), Departments of Biomedicinal Chemistry Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain.
Casasampere M; Research Unit on BioActive Molecules (RUBAM), Departments of Biomedicinal Chemistry Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain.
Sanllehí P; Research Unit on BioActive Molecules (RUBAM), Departments of Biomedicinal Chemistry Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain Faculty of Pharmacy, Unit of Pharmaceutical Chemistry (Associated Unit to CSIC), University of Barcelona, E-08028 Barcelona, Spain.
Casas J; Research Unit on BioActive Molecules (RUBAM), Departments of Biomedicinal Chemistry Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain.
Bujons J; Biological Chemistry and Molecular Modeling, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain.
Fabrias G; Research Unit on BioActive Molecules (RUBAM), Departments of Biomedicinal Chemistry Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain.

J Lipid Res ; 55(8): 1711-20, 2014 Aug.

Article en En | MEDLINE | ID: mdl-24875537

Asunto(s)

Autofagia/efectos de los fármacos; Inhibidores Enzimáticos/farmacología; Oxidorreductasas/antagonistas & inhibidores; Oxidorreductasas/metabolismo; Fosfotransferasas (Aceptor de Grupo Alcohol)/antagonistas & inhibidores; Fase G1/efectos de los fármacos; Células HeLa; Humanos; Metanol; Pirrolidinas/farmacología; Fase de Descanso del Ciclo Celular/efectos de los fármacos; Sulfonas/farmacología

Palabras clave

autophagy; cell cycle; enzyme inhibition; mass spectrometry; molecular docking; reduced nicotinamide adenine dinucleotide-cytochrome b5 reductase; sphingolipids; sphingosine kinase inhibitor II

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidorreductasas / Autofagia / Fosfotransferasas (Aceptor de Grupo Alcohol) / Inhibidores Enzimáticos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Lipid Res Año: 2014 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos

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