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Selective ß2-adrenergic Antagonist Butoxamine Reduces Orthodontic Tooth Movement.
Sato, T; Miyazawa, K; Suzuki, Y; Mizutani, Y; Uchibori, S; Asaoka, R; Arai, M; Togari, A; Goto, S.
Afiliación
  • Sato T; Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan tk-mail@dpc.agu.ac.jp.
  • Miyazawa K; Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
  • Suzuki Y; Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
  • Mizutani Y; Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
  • Uchibori S; Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
  • Asaoka R; Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
  • Arai M; Department of Pharmacology, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan Department of Dental Hygiene, Aichi-Gakuin Junior College, Nagoya, Japan.
  • Togari A; Department of Pharmacology, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
  • Goto S; Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
J Dent Res ; 93(8): 807-12, 2014 Aug.
Article en En | MEDLINE | ID: mdl-24868013
Recently, involvement of the sympathetic nervous system in bone metabolism has attracted attention. ß2-Adrenergic receptor (ß2-AR) is presented on osteoblastic and osteoclastic cells. We previously demonstrated that ß-AR blockers at low dose improve osteoporosis with hyperactivity of the sympathetic nervous system via ß2-AR blocking, while they may have a somewhat inhibitory effect on osteoblastic activity at high doses. In this study, the effects of butoxamine (BUT), a specific ß2-AR antagonist, on tooth movement were examined in spontaneously hypertensive rats (SHR) showing osteoporosis with hyperactivity of the sympathetic nervous system. We administered BUT (1 mg/kg) orally, and closed-coil springs were inserted into the upper-left first molar. After sacrifice, we calculated the amount of tooth movement and analyzed the trabecular microarchitecture and histomorphometry. The distance in the SHR control was greater than that in the Wistar-Kyoto rat group, but no significant difference was found in the SHR treated with BUT compared with the Wistar-Kyoto rat control. Analysis of bone volume per tissue volume, trabecular number, and osteoclast surface per bone surface in the alveolar bone showed clear bone loss by an increase of bone resorption in SHR. In addition, BUT treatment resulted in a recovery of alveolar bone loss. Furthermore, TH-immunoreactive nerves in the periodontal ligament were increased by tooth movement, and BUT administration decreased TH-immunoreactive nerves. These results suggest that BUT prevents alveolar bone loss and orthodontic tooth movement via ß2-AR blocking.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas de Movimiento Dental / Butoxamina / Proceso Alveolar / Antagonistas de Receptores Adrenérgicos beta 2 Límite: Animals Idioma: En Revista: J Dent Res Año: 2014 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas de Movimiento Dental / Butoxamina / Proceso Alveolar / Antagonistas de Receptores Adrenérgicos beta 2 Límite: Animals Idioma: En Revista: J Dent Res Año: 2014 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos