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Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer.
Cihoric, N; Savic, S; Schneider, S; Ackermann, I; Bichsel-Naef, M; Schmid, R A; Lardinois, D; Gugger, M; Bubendorf, L; Zlobec, I; Tapia, C.
Afiliación
  • Cihoric N; Department of Radiation Oncology, University Hospital/Inselspital Bern and University of Bern, 3010 Bern, Switzerland.
  • Savic S; Institute for Pathology, University Hospital Basel, 4003 Basel, Switzerland.
  • Schneider S; Institute for Pathology, University Hospital Basel, 4003 Basel, Switzerland.
  • Ackermann I; Institute for Pathology, University Hospital Basel, 4003 Basel, Switzerland.
  • Bichsel-Naef M; Institute for Pathology, University Bern, 3010 Bern, Switzerland.
  • Schmid RA; Division of General Thoracic Surgery, University Hospital/Inselspital Bern, 3010 Bern, Switzerland.
  • Lardinois D; Division of Thoracic Surgery, University Hospital Basel, 4031 Basel, Switzerland.
  • Gugger M; 1] Institute for Pathology, University Bern, 3010 Bern, Switzerland [2] Promed Laboratoire Médical, 1723 Marley, Switzerland.
  • Bubendorf L; Institute for Pathology, University Hospital Basel, 4003 Basel, Switzerland.
  • Zlobec I; 1] Institute for Pathology, University Hospital Basel, 4003 Basel, Switzerland [2] Institute for Pathology, University Bern, 3010 Bern, Switzerland.
  • Tapia C; 1] Institute for Pathology, University Hospital Basel, 4003 Basel, Switzerland [2] Institute for Pathology, University Bern, 3010 Bern, Switzerland.
Br J Cancer ; 110(12): 2914-22, 2014 Jun 10.
Article en En | MEDLINE | ID: mdl-24853178
BACKGROUND: Recently, fibroblast growth factor receptor 1 (FGFR1) was discovered in squamous cell carcinomas (SCC) of the lung with FGFR1 amplification described as a promising predictive marker for anti-FGFR inhibitor treatment. Only few data are available regarding prevalence, prognostic significance and clinico-pathological characteristics of FGFR1-amplified and early-stage non-small cell lung carcinomas (NSCLC). We therefore investigated the FGFR1 gene status in a large number of well-characterised early-stage NSCLC. METHODS: FGFR1 gene status was evaluated using a commercially available fluorescent in situ hybridisation (FISH) probe on a tissue microarray (TMA). This TMA harbours 329 resected, formalin-fixed and paraffin-embedded, nodal-negative NSCLC with a UICC stage I-II. The FISH results were correlated with clinico-pathological features and overall survival (OS). RESULTS: The prevalence of an FGFR1 amplification was 12.5% (41/329) and was significantly (P<0.0001) higher in squamous cell carcinoma (SCC) (20.7%) than in adenocarcinoma (2.2%) and large cell carcinoma (13%). Multivariate analysis revealed significantly (P=0.0367) worse 5-year OS in patients with an FGFR1-amplified NSCLC. CONCLUSIONS: FGFR1 amplification is common in early-stage SCC of the lung and is an independent and adverse prognostic marker. Its potential role as a predictive marker for targeted therapies or adjuvant treatment needs further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Amplificación de Genes / Carcinoma de Pulmón de Células no Pequeñas / Receptor Tipo 1 de Factor de Crecimiento de Fibroblastos / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Año: 2014 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Amplificación de Genes / Carcinoma de Pulmón de Células no Pequeñas / Receptor Tipo 1 de Factor de Crecimiento de Fibroblastos / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Año: 2014 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido