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Spatial and temporal expression of RA70/Scap2 in the developing neural tube.
Tanabe, Yuko; Shiota, Akira; Kouroku-Murakami, Yoriko; Fujita-Jimbo, Eriko; Urase, Koko; Takahashi, Kana; Mezaki, Yoshihiro; Senoo, Haruki; Momoi, Takashi.
Afiliación
  • Tanabe Y; Center for Medical Science, International University of Health and Welfare, Kitakanemaru, Ohtawara, Tochigi, Japan.
  • Shiota A; PhoenixBio, Ltd., Iwazo, Utsunomiya, Tochigi, Japan.
  • Kouroku-Murakami Y; Center for Medical Science, International University of Health and Welfare, Kitakanemaru, Ohtawara, Tochigi, Japan.
  • Fujita-Jimbo E; Center for Medical Science, International University of Health and Welfare, Kitakanemaru, Ohtawara, Tochigi, Japan; Department of Pediatrics, Jichi Medical University, Yakushiji, Shimotsukeshi, Tochigi, Japan.
  • Urase K; Department of Biology, School of Medicine Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.
  • Takahashi K; Department of Cell Biology and Morphology, Akita University Graduate School of Medicine, Hondo, Akita, Japan.
  • Mezaki Y; Department of Cell Biology and Morphology, Akita University Graduate School of Medicine, Hondo, Akita, Japan.
  • Senoo H; Department of Cell Biology and Morphology, Akita University Graduate School of Medicine, Hondo, Akita, Japan.
  • Momoi T; Center for Medical Science, International University of Health and Welfare, Kitakanemaru, Ohtawara, Tochigi, Japan. Electronic address: momoi@iuhw.ac.jp.
Neurosci Lett ; 576: 1-5, 2014 Jul 25.
Article en En | MEDLINE | ID: mdl-24846415
Src kinase-associated phosphoprotein 2 (Ra70/scap2), which was originally isolated as a retinoic acid (RA)-induced gene, associates with molecules that modulate integrin-survival signals. Although RA is essential for vertebrate organogenesis in the posterior region, little is known about the biological role of RA70/Scap2 during development. In the present study, we demonstrate that Ra70/scap2 mRNA is temporally expressed during the RA-induced neuronal differentiation of P19 embryonic carcinoma cells. Homozygous knockout mice in which the Ra70/scap2 gene was replaced with LacZ exhibited embryonic lethality, while heterozygous mice displayed preferential expression of LacZ in posterior neural tissues, including the neural tube and hindbrain during development (E7.5-11.5), but not the forebrain. Ra70/scap2 was expressed in the ependymal layer and ventricular zone in the neural tube, where neuroepithelial cells and neuroblasts with proliferation capacity are localized, respectively. Thus, RA70/Scap2 may be necessary for RA-induced neuronal differentiation from the posterior neuroectoderm.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos y Proteínas de Señalización Intracelular / Tubo Neural Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2014 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos y Proteínas de Señalización Intracelular / Tubo Neural Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2014 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda