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A Network Map of FGF-1/FGFR Signaling System.
Raju, Rajesh; Palapetta, Shyam Mohan; Sandhya, Varot K; Sahu, Apeksha; Alipoor, Abbas; Balakrishnan, Lavanya; Advani, Jayshree; George, Bijesh; Kini, K Ramachandra; Geetha, N P; Prakash, H S; Prasad, T S Keshava; Chang, Yu-Jung; Chen, Linyi; Pandey, Akhilesh; Gowda, Harsha.
Afiliación
  • Raju R; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Palapetta SM; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India ; Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
  • Sandhya VK; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Sahu A; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India ; Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
  • Alipoor A; Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India.
  • Balakrishnan L; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Advani J; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • George B; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Kini KR; Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India.
  • Geetha NP; Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India.
  • Prakash HS; Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India.
  • Prasad TS; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Chang YJ; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
  • Chen L; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
  • Pandey A; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Pathology, Johns Hopkins University School of Medicine, Ba
  • Gowda H; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
J Signal Transduct ; 2014: 962962, 2014.
Article en En | MEDLINE | ID: mdl-24829797
Fibroblast growth factor-1 (FGF-1) is a well characterized growth factor among the 22 members of the FGF superfamily in humans. It binds to all the four known FGF receptors and regulates a plethora of functions including cell growth, proliferation, migration, differentiation, and survival in different cell types. FGF-1 is involved in the regulation of diverse physiological processes such as development, angiogenesis, wound healing, adipogenesis, and neurogenesis. Deregulation of FGF-1 signaling is not only implicated in tumorigenesis but also is associated with tumor invasion and metastasis. Given the biomedical significance of FGFs and the fact that individual FGFs have different roles in diverse physiological processes, the analysis of signaling pathways induced by the binding of specific FGFs to their cognate receptors demands more focused efforts. Currently, there are no resources in the public domain that facilitate the analysis of signaling pathways induced by individual FGFs in the FGF/FGFR signaling system. Towards this, we have developed a resource of signaling reactions triggered by FGF-1/FGFR system in various cell types/tissues. The pathway data and the reaction map are made available for download in different community standard data exchange formats through NetPath and NetSlim signaling pathway resources.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Signal Transduct Año: 2014 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Signal Transduct Año: 2014 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos