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Excitatory synaptic feedback from the motor layer to the sensory layers of the superior colliculus.
Ghitani, Nima; Bayguinov, Peter O; Vokoun, Corinne R; McMahon, Shane; Jackson, Meyer B; Basso, Michele A.
Afiliación
  • Ghitani N; Department of Neuroscience, Neuroscience Training Program.
  • Bayguinov PO; Department of Neuroscience.
  • Vokoun CR; Department of Neuroscience, Molecular and Cellular Pharmacology Training Program, and.
  • McMahon S; Molecular Biophysics Ph.D. Program, University of Wisconsin-Madison, Madison, Wisconsin 53706, and.
  • Jackson MB; Department of Neuroscience, mbasso@mednet.ucla.edu mbjackso@wisc.edu.
  • Basso MA; Department of Neuroscience, Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior University of California at Los Angeles, Los Angeles, California 90095-7332 mbasso@mednet.ucla.edu mbjackso@wisc.edu.
J Neurosci ; 34(20): 6822-33, 2014 May 14.
Article en En | MEDLINE | ID: mdl-24828636
Neural circuits that translate sensory information into motor commands are organized in a feedforward manner converting sensory information into motor output. The superior colliculus (SC) follows this pattern as it plays a role in converting visual information from the retina and visual cortex into motor commands for rapid eye movements (saccades). Feedback from movement to sensory regions is hypothesized to play critical roles in attention, visual image stability, and saccadic suppression, but in contrast to feedforward pathways, motor feedback to sensory regions has received much less attention. The present study used voltage imaging and patch-clamp recording in slices of rat SC to test the hypothesis of an excitatory synaptic pathway from the motor layers of the SC back to the sensory superficial layers. Voltage imaging revealed an extensive depolarization of the superficial layers evoked by electrical stimulation of the motor layers. A pharmacologically isolated excitatory synaptic potential in the superficial layers depended on stimulus strength in the motor layers in a manner consistent with orthodromic excitation. Patch-clamp recording from neurons in the sensory layers revealed excitatory synaptic potentials in response to glutamate application in the motor layers. The location, size, and morphology of responsive neurons indicated they were likely to be narrow-field vertical cells. This excitatory projection from motor to sensory layers adds an important element to the circuitry of the SC and reveals a novel feedback pathway that could play a role in enhancing sensory responses to attended targets as well as visual image stabilization.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Colículos Superiores / Potenciales Postsinápticos Excitadores / Retroalimentación Fisiológica / Neuronas Límite: Animals Idioma: En Revista: J Neurosci Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Colículos Superiores / Potenciales Postsinápticos Excitadores / Retroalimentación Fisiológica / Neuronas Límite: Animals Idioma: En Revista: J Neurosci Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos