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Causative organisms in revision total hip & knee arthroplasty for infection: Increasing multi-antibiotic resistance in coagulase-negative Staphylococcus and the implications for antibiotic prophylaxis.
Malhas, A M; Lawton, R; Reidy, M; Nathwani, D; Clift, B A.
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  • Malhas AM; Department of Trauma and Orthopaedics, Ward 18/19, Ninewells Hospital, NHS Tayside, Dundee, Scotland DD2 1UB, UK. Electronic address: amarmalhas@nhs.net.
  • Lawton R; Department of Trauma and Orthopaedics, Ward 18/19, Ninewells Hospital, NHS Tayside, Dundee, Scotland DD2 1UB, UK.
  • Reidy M; Department of Trauma and Orthopaedics, Ward 18/19, Ninewells Hospital, NHS Tayside, Dundee, Scotland DD2 1UB, UK.
  • Nathwani D; Department of Infectious Diseases, Ward 18/19, Ninewells Hospital, NHS Tayside, Dundee, Scotland DD2 1UB, UK.
  • Clift BA; Department of Trauma and Orthopaedics, Ward 18/19, Ninewells Hospital, NHS Tayside, Dundee, Scotland DD2 1UB, UK.
Surgeon ; 13(5): 250-5, 2015 Oct.
Article en En | MEDLINE | ID: mdl-24821264
BACKGROUND AND PURPOSE: Increasing resistance among post-operative Coagulase-negative Staphylococci (CNS) infections have been reported. We present our experience changing resistance patterns. METHODS: We examined microbiological results from hip and knee revisions from 2001 to 2010 and compared resistance to all Staphylococcus aureus (SA) and CNS cultured from regional pan-speciality sources, in order to examine the patterns of antibiotic resistance. MAIN FINDINGS: 72 revisions in 67 patients were included. The most common organisms were SA (36%) and CNS (35%). Resistance to methicillin was 72% for CNS versus 20% for SA and resistance to gentamicin was 40% for CNS versus 4% for SA. Among all regional (background pan-speciality) cultures SA resistance to methicillin fell from 32% to 16% from 2006 to 10 with no change in gentamicin resistance at 3%. During the same period resistance of CNS to methicillin and gentamicin increased from 63% to 70% and 32%-47% respectively. CONCLUSIONS: Resistance of CNS to both methicillin and gentamicin is higher than with SA and appears to be increasing. At least 32% of CNS and 4% of SA from infected TKRs/THRs were resistant to our current prophylaxis regime. These changing patterns of resistance may have implications for future antibiotic prophylaxis regimes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Infecciones Relacionadas con Prótesis / Coagulasa / Profilaxis Antibiótica / Artroplastia de Reemplazo de Cadera / Artroplastia de Reemplazo de Rodilla / Farmacorresistencia Bacteriana Múltiple Tipo de estudio: Observational_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Surgeon Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Infecciones Relacionadas con Prótesis / Coagulasa / Profilaxis Antibiótica / Artroplastia de Reemplazo de Cadera / Artroplastia de Reemplazo de Rodilla / Farmacorresistencia Bacteriana Múltiple Tipo de estudio: Observational_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Surgeon Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido