Your browser doesn't support javascript.
loading
Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of ß-catenin.
Durak, O; de Anda, F C; Singh, K K; Leussis, M P; Petryshen, T L; Sklar, P; Tsai, L-H.
Afiliación
  • Durak O; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • de Anda FC; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Singh KK; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Leussis MP; 1] Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA [2] Department of Psychiatry, Harvard Medical School, Boston, MA, USA [3] Stanley Center for Psychiatric Research, Broad Institute of H
  • Petryshen TL; 1] Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA [2] Department of Psychiatry, Harvard Medical School, Boston, MA, USA [3] Stanley Center for Psychiatric Research, Broad Institute of H
  • Sklar P; Division of Psychiatric Genomics, Departments of Psychiatry, Neuroscience and Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA.
  • Tsai LH; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Mol Psychiatry ; 20(3): 388-97, 2015 Mar.
Article en En | MEDLINE | ID: mdl-24821222
Ankyrin-G is a scaffolding protein required for the formation of the axon initial segment in neurons. Recent genome-wide association studies and whole-exome sequencing have identified ANK3, the gene coding for ankyrin-G, to be a risk gene for multiple neuropsychiatric disorders, such as bipolar disorder, schizophrenia and autism spectrum disorder. Here, we describe a novel role for ankyrin-G in neural progenitor proliferation in the developing cortex. We found that ankyrin-G regulates canonical Wnt signaling by altering the subcellular localization and availability of ß-catenin in proliferating cells. Ankyrin-G loss-of-function increases ß-catenin levels in the nucleus, thereby promoting neural progenitor proliferation. Importantly, abnormalities in proliferation can be rescued by reducing Wnt pathway signaling. Taken together, these results suggest that ankyrin-G is required for proper brain development.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fracciones Subcelulares / Actinas / Proteínas Wnt / Neurogénesis / Vía de Señalización Wnt / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Pregnancy Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fracciones Subcelulares / Actinas / Proteínas Wnt / Neurogénesis / Vía de Señalización Wnt / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Pregnancy Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido