Preparation and enantioselectivity binding studies of a new chiral cobalt(II)porphyrin-Tröger's base conjugate.

Tatar, Ameneh; Valík, Martin; Novotná, Jana; Havlík, Martin; Dolenský, Bohumil; Král, Vladimír; Urbanová, Marie

Tatar, Ameneh; Valík, Martin; Novotná, Jana; Havlík, Martin; Dolenský, Bohumil; Král, Vladimír; Urbanová, Marie.

Afiliación

Tatar A; Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic.

Chirality ; 26(8): 361-7, 2014 Aug.

Article en En | MEDLINE | ID: mdl-24819313

RESUMEN

A new bis[cobalt(II)porphyrin]-Tröger's base conjugate was studied as a potential receptor for methyl esters of several amino acids. The conjugate was prepared as racemate, and then resolved via preparative high-performance liquid chromatography (HPLC) on a chiral column. The high affinity to lysine, histidine, and proline methyl esters was found by complexation studies followed by UV-Vis spectroscopy. The studies of pure enantiomers, followed by UV-Vis and electronic circular dichroism spectroscopy, revealed the highest enantioselectivity for lysine methyl ester.

Palabras clave

Tröger's base conjugate; chiral receptors; enantioselectivity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chirality Asunto de la revista: BIOLOGIA MOLECULAR / QUIMICA Año: 2014 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos

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