[Antigenic determinants of the constant region of human immunoglobin kappa-chain detected by monoclonal antibodies]. / Antigennye determinanty postoiannogo domena kappa-tsepei immunoglobulinov cheloveka, vyiavliaemye s pomoshch'iu monoklonal'nykh antitel.
Mol Biol (Mosk)
; 23(5): 1227-33, 1989.
Article
en Ru
| MEDLINE
| ID: mdl-2481811
Ten different monoclonal antibody (monAB) preparations reacting with human IgL chains of the kappa type have been obtained. Nine of the monAB interacted with the kappa-chain C domain, whereas only one monAB reacted with the V domain. It has been determined that monAB against the C domain react with three different epitopes. One epitope is expressed on intact Ig molecules as well as on isolated kappa-chains, whereas the other two epitopes are found only on isolated kappa-chains. The expression of these epitopes in 40 different myeloma kappa-chain preparations belonging to four various subgroups was studied. The level of this C domain epitope expression has been shown to depend on the variable subgroups of kappa-chains indicating a close association between V and C domains. This association leads to the alteration of antigenic activity of some C domain epitopes. The alterations are thought to be local because, as a rule, they involve only one of the three epitopes.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regiones Constantes de Inmunoglobulina
/
Cadenas kappa de Inmunoglobulina
/
Anticuerpos Monoclonales
/
Epítopos
Límite:
Humans
Idioma:
Ru
Revista:
Mol Biol (Mosk)
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Rusia