Your browser doesn't support javascript.
loading
Alpha-B-crystallin expression in human laryngeal squamous cell carcinoma tissues.
Yilmaz, Mehmet; Karatas, Omer Faruk; Yuceturk, Betul; Dag, Huseyin; Yener, Murat; Ozen, Mustafa.
Afiliación
  • Yilmaz M; Department of Otorhinolaryngology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
  • Karatas OF; Department of Medical Genetics, Istanbul University Cerrahpasa Medical School, Istanbul, Turkey.
  • Yuceturk B; Molecular Biology and Genetics Department, Erzurum Technical University, Erzurum, Turkey.
  • Dag H; Department of Medical Genetics, Istanbul University Cerrahpasa Medical School, Istanbul, Turkey.
  • Yener M; Department of Otorhinolaryngology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
  • Ozen M; Department of Otorhinolaryngology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
Head Neck ; 37(9): 1344-8, 2015 Sep.
Article en En | MEDLINE | ID: mdl-24817638
BACKGROUND: Laryngeal squamous cell carcinoma (SCC), being an aggressive malignancy, is one of the most commonly diagnosed malignant types of head and neck SCC worldwide. The recent studies suggested that αB-crystallin might play an important role in tumorigenesis. The purpose of this study was to investigate the αB-crystallin expression level in metastatic and nonmetastatic laryngeal SCC tissues and to determine its prognostic significance. METHODS: Alpha-B-crystallin expression status in metastatic, nonmetastatic laryngeal SCC, and normal tissue samples was investigated by quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: We demonstrated that the expression of αB-crystallin was significantly upregulated in laryngeal SCC tumor tissue samples in comparison with the corresponding normal tissues (p < .001), although no significant association has been found between αB-crystallin expression and either the metastatic potential or the T classification of the specimens. CONCLUSION: Although expression of αB-crystallin is not statistically correlated with neck metastases, we demonstrated that αB-crystallin is significantly overexpressed in laryngeal cancer.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias Laríngeas / Cadena B de alfa-Cristalina / Neoplasias de Cabeza y Cuello / Ganglios Linfáticos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias Laríngeas / Cadena B de alfa-Cristalina / Neoplasias de Cabeza y Cuello / Ganglios Linfáticos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos