Amplitude-integrated electroencephalography shows that doxapram influences the brain activity of preterm infants.
Acta Paediatr
; 103(9): 922-7, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-24813556
AIM: The aim of this study was to measure the brain activity of preterm infants treated with caffeine citrate and doxapram for preterm apnoea, using amplitude-integrated electroencephalography (aEEG), to identify any adverse effects on cerebral function. METHODS: We analysed the aEEG tracings of 13 preterm infants <30 weeks of gestation before, during and after doxapram treatment, with regard to background activity (percentages of continuous and discontinuous patterns), occurrence of sleep-wake cycling and appearance of electrographic seizure activity. They were also compared with 61 controls without doxapram treatment. RESULTS: During doxapram treatment, aEEG tracings showed an increase in continuous background activity (19 ± 30% before treatment, 38 ± 35% during treatment) and a decrease in discontinuous patterns. In addition, they showed more frequent electrographic seizure activity (0% before treatment, 15 ± 37% during treatment) and less frequent sleep-wake cycling (92 ± 27% before treatment, 85 ± 37% during treatment) could be observed. These results were confirmed when compared to the control group. CONCLUSION: Doxapram treatment influences aEEG in preterm infants, showing higher percentages of continuous activity as well as more electrographic seizure activity and less sleep-wake cycling. It should, therefore, be used with caution in very preterm infants.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
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Fármacos del Sistema Respiratorio
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Doxapram
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Electroencefalografía
Tipo de estudio:
Observational_studies
Límite:
Female
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Humans
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Male
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Newborn
Idioma:
En
Revista:
Acta Paediatr
Año:
2014
Tipo del documento:
Article
País de afiliación:
Austria
Pais de publicación:
Noruega