Your browser doesn't support javascript.
loading
Pleuromutilins: use in food-producing animals in the European Union, development of resistance and impact on human and animal health.
van Duijkeren, Engeline; Greko, Christina; Pringle, Märit; Baptiste, Keith Edward; Catry, Boudewijn; Jukes, Helen; Moreno, Miguel A; Pomba, M Constança Matias Ferreira; Pyörälä, Satu; Rantala, Merja; Ruzauskas, Modestas; Sanders, Pascal; Teale, Christopher; Threlfall, E John; Torren-Edo, Jordi; Törneke, Karolina.
Afiliación
  • van Duijkeren E; National Institute for Public Health and the Environment, Bilthoven, The Netherlands engeline.van.duijkeren@rivm.nl.
  • Greko C; National Veterinary Institute, Uppsala, Sweden.
  • Pringle M; National Veterinary Institute, Uppsala, Sweden.
  • Baptiste KE; Danish Health and Medicines Authority, Copenhagen, Denmark.
  • Catry B; Scientific Institute of Public Health, Brussels, Belgium.
  • Jukes H; Veterinary Medicines Directorate, Addlestone, UK.
  • Moreno MA; Faculty of Veterinary Medicine, Complutense University, Madrid, Spain.
  • Pomba MC; Faculty of Veterinary Medicine, Technical University of Lisbon, Portugal.
  • Pyörälä S; Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
  • Rantala M; Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
  • Ruzauskas M; Veterinary Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Sanders P; Agence Nationale de Sécurité Sanitaire (ANSES), Fougères, France.
  • Teale C; Veterinary Laboratories Agency, New Haw, UK.
  • Threlfall EJ; Health Protection Agency, London, UK.
  • Torren-Edo J; European Medicines Agency, London, UK.
  • Törneke K; Läkemedelsverket, Uppsala, Sweden.
J Antimicrob Chemother ; 69(8): 2022-31, 2014 Aug.
Article en En | MEDLINE | ID: mdl-24793902
Pleuromutilins (tiamulin and valnemulin) are antimicrobial agents that are used mainly in veterinary medicine, especially for swine and to a lesser extent for poultry and rabbits. In pigs, tiamulin and valnemulin are used to treat swine dysentery, spirochaete-associated diarrhoea, porcine proliferative enteropathy, enzootic pneumonia and other infections where Mycoplasma is involved. There are concerns about the reported increases in the MICs of tiamulin and valnemulin for porcine Brachyspira hyodysenteriae isolates from different European countries, as only a limited number of antimicrobials are available for the treatment of swine dysentery where resistance to these antimicrobials is already common and widespread. The loss of pleuromutilins as effective tools to treat swine dysentery because of further increases in resistance or as a consequence of restrictions would present a considerable threat to pig health, welfare and productivity. In humans, only one product containing pleuromutilins (retapamulin) is authorized currently for topical use; however, products for oral and intravenous administration to humans with serious multidrug-resistant skin infections and respiratory infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA), are being developed. The objective of this review is to summarize the current knowledge on the usage of pleuromutilins, resistance development and the potential impact of this resistance on animal and human health.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de las Aves de Corral / Enfermedades de los Porcinos / Farmacorresistencia Bacteriana / Antibacterianos Límite: Animals / Humans Idioma: En Revista: J Antimicrob Chemother Año: 2014 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de las Aves de Corral / Enfermedades de los Porcinos / Farmacorresistencia Bacteriana / Antibacterianos Límite: Animals / Humans Idioma: En Revista: J Antimicrob Chemother Año: 2014 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido