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Interleukin-1beta -511T>C genetic variant contributes to recurrent pregnancy loss risk and peripheral natural killer cell proportion.
Kim, Jung O; Lee, Woo Sik; Lee, Bo Eun; Jeon, Young Joo; Kim, Young Ran; Jung, Sang Hee; Chang, Sung Woon; Kim, Nam Keun.
Afiliación
  • Kim JO; Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, South Korea; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
  • Lee WS; Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, South Korea.
  • Lee BE; Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, South Korea; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
  • Jeon YJ; Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, South Korea; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
  • Kim YR; Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
  • Jung SH; Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
  • Chang SW; Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
  • Kim NK; Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, South Korea; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea. Electronic address: nkkim@cha.ac.kr.
Fertil Steril ; 102(1): 206-212.e5, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24784935
OBJECTIVE: To identify whether interleukin gene polymorphisms are risk factors for idiopathic recurrent pregnancy loss (RPL) in Korean women. DESIGN: Case-control study. SETTING: Hospital-based study. PATIENT(S): A cohort of 385 idiopathic RPL patients and 232 controls with Korean ethnicity. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Genotyping was assessed with a polymerase chain reaction-restriction fragment length polymorphism assay. We examined polymorphisms in three interleukin (IL) genes: IL-1ß, IL-4, and IL-10. RESULT(S): The IL-1ß -511T>C polymorphism was associated with RPL (-511TT vs. -511CC: adjusted odds ratio 1.826; 95% confidence interval 1.130-2.953). Allelic gene-gene interaction analysis revealed that the T/B2/G (IL-1ß/IL-4/IL-10) allele combination was only detected in the RPL group (adjusted odds ratio 20.046; 95% confidence interval 1.188-338.204). The proportion of peripheral natural killer cells was higher in patients with the IL-1ß -511C allele compared with the -511T allele. CONCLUSION(S): According to these results, IL-1ß -511T>C may be a predisposing factor to RPL susceptibility. However, the mechanism underlying the function of IL-1ß -511T>C in RPL remains to be determined, and further studies are needed to improve understanding of the roles of IL-1ß -511T>C, using a larger and more heterogeneous cohort.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Células Asesinas Naturales / Aborto Habitual / Interleucina-1beta Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Fertil Steril Año: 2014 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Células Asesinas Naturales / Aborto Habitual / Interleucina-1beta Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Fertil Steril Año: 2014 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos