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Trichohyalin-like proteins have evolutionarily conserved roles in the morphogenesis of skin appendages.
Mlitz, Veronika; Strasser, Bettina; Jaeger, Karin; Hermann, Marcela; Ghannadan, Minoo; Buchberger, Maria; Alibardi, Lorenzo; Tschachler, Erwin; Eckhart, Leopold.
Afiliación
  • Mlitz V; Department of Dermatology, Medical University of Vienna, Vienna, Austria.
  • Strasser B; Department of Dermatology, Medical University of Vienna, Vienna, Austria.
  • Jaeger K; Department of Dermatology, Medical University of Vienna, Vienna, Austria.
  • Hermann M; Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria.
  • Ghannadan M; Department of Dermatology, Medical University of Vienna, Vienna, Austria.
  • Buchberger M; Department of Dermatology, Medical University of Vienna, Vienna, Austria.
  • Alibardi L; Dipartimento di Scienze Biologiche, Geologiche ed Ambientali (BiGeA), Università di Bologna, Bologna, Italy.
  • Tschachler E; Department of Dermatology, Medical University of Vienna, Vienna, Austria.
  • Eckhart L; Department of Dermatology, Medical University of Vienna, Vienna, Austria. Electronic address: leopold.eckhart@meduniwien.ac.at.
J Invest Dermatol ; 134(11): 2685-2692, 2014 Nov.
Article en En | MEDLINE | ID: mdl-24780931
S100 fused-type proteins (SFTPs) such as filaggrin, trichohyalin, and cornulin are differentially expressed in cornifying keratinocytes of the epidermis and various skin appendages. To determine evolutionarily conserved, and thus presumably important, features of SFTPs, we characterized nonmammalian SFTPs and compared their amino acid sequences and expression patterns with those of mammalian SFTPs. We identified an ortholog of cornulin and a previously unknown SFTP, termed scaffoldin, in reptiles and birds, whereas filaggrin was confined to mammals. In contrast to mammalian SFTPs, both cornulin and scaffoldin of the chicken are expressed in the embryonic periderm. However, scaffoldin resembles mammalian trichohyalin with regard to its expression in the filiform papillae of the tongue and in the epithelium underneath the forming tips of the claws. Furthermore, scaffoldin is expressed in the epithelial sheath around growing feathers, reminiscent of trichohyalin expression in the inner root sheath of hair. The results of this study show that SFTP-positive epithelia function as scaffolds for the growth of diverse skin appendages such as claws, nails, hair, and feathers, indicating a common evolutionary origin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación del Desarrollo de la Expresión Génica / Proteínas Aviares / Epitelio / Proteínas de la Membrana / Proteínas de Neoplasias Límite: Animals / Humans Idioma: En Revista: J Invest Dermatol Año: 2014 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación del Desarrollo de la Expresión Génica / Proteínas Aviares / Epitelio / Proteínas de la Membrana / Proteínas de Neoplasias Límite: Animals / Humans Idioma: En Revista: J Invest Dermatol Año: 2014 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos