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Cognition may be related to arterial pulsatility index in HD patients.
Post, James B; Morin, Kel G; Handrakis, John P; Rivera, Dwindally Rosado; Yen, Christina; Sano, Mary; Spungen, Ann M.
Afiliación
  • Post JB; Nephrology Division, VA RR&D Center of Excellence for Medical Consequences of SCI, James J. Peters Veterans Affairs Medical Center, Bronx, NY, Department of Physical Therapy, School of Health Professionals, New York Institute of Technology, Old Westbury, NY, VA RR&D, James J. Peters Veterans Affairs Medical Center, Bronx, NY, Departments of Medicine, Psychiatry, and Rehabilitation Medicine, Mount Sinai School of Medicine, NY, USA.
Clin Nephrol ; 81(5): 313-9, 2014 May.
Article en En | MEDLINE | ID: mdl-24780553
AIMS: Hemodialysis (HD) patients have a heavy burden of subclinical cerebrovascular disease and cognitive changes consistent with a vascular etiology. Pulsatility index is associated with microangiopathy of cerebral blood vessels and an increased risk of cerebral infarction. The proposed study was to determine common carotid artery pulsatility index (CCAPI) and its relation to cognition in well-dialyzed HD patients with no history of stroke or dementia and matched controls. METHODS: Observational, cross-sectional study of CCAPI and cognition in 37 hemodialysis outpatients and 18 matched controls with normal kidney function. Non-parametric analyses were used to compare variables between groups. Multiple regression and ANOVA models were used to adjust for risk factor differences. RESULTS: Controls had a lower CCAPI than the HD group (1.7 ± 0.3 vs. 2.1 ± 0.4 cm/s, p = 0.006). HD patients scored significantly lower on all cognitive domains. Attention correlated with CCAPI in HD patients, independent of hypertension, diabetes, hyperlipidemia, and years on HD (r2 = -0.36, p = 0.01). CCAPI correlated with years on HD, independent of traditional cardiovascular risk factors. (r2 = 0.26, p = 0.04). CONCLUSION: In well-dialyzed hemodialysis patients with no history of stroke or dementia, CCAPI may correlate with cognitive function and represent a marker for underlying cerebral microvascular disease.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flujo Pulsátil / Diálisis Renal / Arteria Carótida Común / Cognición Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Middle aged Idioma: En Revista: Clin Nephrol Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flujo Pulsátil / Diálisis Renal / Arteria Carótida Común / Cognición Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Middle aged Idioma: En Revista: Clin Nephrol Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania