Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes.
Implant Dent
; 23(3): 319-27, 2014 Jun.
Article
en En
| MEDLINE
| ID: mdl-24776941
PURPOSE: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing. METHODS: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 × 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD). RESULTS: At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls. CONCLUSIONS: Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Extracción Dental
/
Cicatrización de Heridas
/
Implantes Dentales
/
Diabetes Mellitus Tipo 2
/
Hipoglucemiantes
/
Metformina
Límite:
Animals
Idioma:
En
Revista:
Implant Dent
Asunto de la revista:
ODONTOLOGIA
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Estados Unidos