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Proinflammatory and prothrombotic state in subjects with different glucose tolerance status before cardiovascular disease.
Isordia-Salas, Irma; Galván-Plata, María Eugenia; Leaños-Miranda, Alfredo; Aguilar-Sosa, Eberth; Anaya-Gómez, Francisco; Majluf-Cruz, Abraham; Santiago-Germán, David.
Afiliación
  • Isordia-Salas I; Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, H.G.R. No. 1 "Dr. Carlos Mac Gregor Sánchez Navarro" Instituto Mexicano del Seguro Social, Apartado Postal B 32, Coahuila No. 5, 06703 México, DF, Mexico.
  • Galván-Plata ME; Servicio de Medicina Interna, UMAE, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, 06720 México, DF, Mexico.
  • Leaños-Miranda A; Unidad de Investigación Médica en Medicina Reproductiva, UMAE H.G.O. No. 4, Instituto Mexicano del Seguro Social, 01070 México, DF, Mexico.
  • Aguilar-Sosa E; Servicio de Medicina Interna, H.G.Z. A 2 "Francisco del Paso y Troncoso", del Instituto Mexicano del Seguro Social, 08400 México, DF, Mexico.
  • Anaya-Gómez F; Servicio de Medicina Interna, H.G.R. No. 1 "Dr. Carlos Mac Gregor Sánchez Navarro" Instituto Mexicano del Seguro Social, 03100 México, DF, Mexico.
  • Majluf-Cruz A; Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, H.G.R. No. 1 "Dr. Carlos Mac Gregor Sánchez Navarro" Instituto Mexicano del Seguro Social, Apartado Postal B 32, Coahuila No. 5, 06703 México, DF, Mexico.
  • Santiago-Germán D; Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, H.G.R. No. 1 "Dr. Carlos Mac Gregor Sánchez Navarro" Instituto Mexicano del Seguro Social, Apartado Postal B 32, Coahuila No. 5, 06703 México, DF, Mexico ; Servicio de Urgencias, H.G.R. No. 1 "Dr. Carlos Mac Gregor Sánchez Navar
J Diabetes Res ; 2014: 631902, 2014.
Article en En | MEDLINE | ID: mdl-24772446
BACKGROUND: Inflammation has been associated with insulin resistance, type 2 diabetes mellitus (T2DM), and atherothrombosis. AIM: To determine differences in levels of proinflammatory and prothrombotic markers such as high sensitivity C-reactive protein (hs-CRP) and fibrinogen in subjects with normal glucose tolerance (NGT), prediabetes, and T2DM and to establish their relationship with other cardiovascular risk factors before clinical manifestations of cardiovascular disease. METHODS: We conducted a nonrandomized, cross-sectional assay in a hospital at México City. The levels of hs-CRP and fibrinogen were measured and compared according to glucose tolerance status. RESULTS: We enrolled 1047 individuals and they were distributed into NGT n = 473, pre-DM n = 250, and T2DM n = 216. There was a statistical difference between NGT and T2DM groups for fibrinogen (P = 0.01) and hs-CRP (P = 0.05). Fibrinogen and hs-CRP showed a significant positive correlation coefficient (r = 0.53, P<0.0001). In a multiple stepwise regression analysis, the variability in fibrinogen levels was explained by age, HbA1c, and hs-CRP (adjusted R² = 0.31, P<0.0001), and for hs-CRP it was explained by BMI and fibrinogen (adjusted R² = 0.33, P<0.0001). CONCLUSION: Inflammation and prothrombotic state are present in people with T2DM lacking cardiovascular disease. Fibrinogen and Hs-CRP are positively correlated. Fibrinogen and hs-CRP concentrations are predominantly determined by BMI rather than glucose levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Prediabético / Trombosis / Vasculitis / Enfermedades Cardiovasculares / Intolerancia a la Glucosa / Diabetes Mellitus Tipo 2 Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Mexico Idioma: En Revista: J Diabetes Res Año: 2014 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Prediabético / Trombosis / Vasculitis / Enfermedades Cardiovasculares / Intolerancia a la Glucosa / Diabetes Mellitus Tipo 2 Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Mexico Idioma: En Revista: J Diabetes Res Año: 2014 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido