Structural signs of dynamic state of synaptic contacts between neurotransplant and brain.

Zhuravleva, Z N; Khutsian, S S

Zhuravleva, Z N; Khutsian, S S.

Afiliación

Zhuravleva ZN; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Puschino, Russia, zhuravleva@iteb.ru.

Bull Exp Biol Med ; 156(4): 448-51, 2014 Feb.

Article en En | MEDLINE | ID: mdl-24771424

RESUMEN

We studied ultrastructure of synaptic connections between long-living dentate fascia transplants and somatosensory area of the neocortex in rats. Giant synaptic terminals of granular neurons upon contact with unusual neuronal targets in the neocortex reproduced their specific constitutive morphological features. At the same time, developing synapses with signs of active structural and metabolic reorganization were revealed. This is indicative of a dynamic state and instability of functional connections between the transplant and brain despite long time after transplantation.

Asunto(s)

Trasplante de Tejido Encefálico; Giro Dentado/trasplante; Animales; Espinas Dendríticas/ultraestructura; Giro Dentado/citología; Desmosomas/ultraestructura; Masculino; Neocórtex/citología; Terminales Presinápticos/fisiología; Terminales Presinápticos/ultraestructura; Ratas Wistar

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Tejido Encefálico / Giro Dentado Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos

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