Radiation-induced meningiomas in multiple regions, showing rapid recurrence and a high MIB 1 labeling index: a case report and review of the literature.

Goto, Yoshiaki; Yamada, So; Yamada, Shoko M; Nakaguchi, Hiroshi; Hoya, Katsumi; Murakami, Mineko; Yamazaki, Kazuto; Ishida, Yasuo; Matsuno, Akira

Goto, Yoshiaki; Yamada, So; Yamada, Shoko M; Nakaguchi, Hiroshi; Hoya, Katsumi; Murakami, Mineko; Yamazaki, Kazuto; Ishida, Yasuo; Matsuno, Akira.

Afiliación

Goto Y; Department of Neurosurgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara-City, Chiba 299-0111, Japan. gyoshiaki@hotmail.co.jp.

World J Surg Oncol ; 12: 123, 2014 Apr 26.

Article en En | MEDLINE | ID: mdl-24767145

RESUMEN

Combined chemotherapy and prophylactic cranial irradiation has improved the prognosis of children with acute leukemia. However cranial irradiation carries a latent risk of the induction of secondary intracranial tumors. We encountered a patient who developed multiple intracranial radiation-induced meningiomas (RIMs) 25 years after prophylactic cranial irradiation for the treatment of acute leukemia in childhood. The patient had 3 intracranial lesions, 1 of which showed rapid growth within 6 months; another of the tumors also enlarged within a short period. All of the tumors were surgically treated, and immunohistochemistry indicated a high MIB-1 labeling index in each of the multiple lesions. In the literature, the MIB-1 labeling indices of 27 tumors from 21 patients were examined. Among them, 12 recurrent tumors showed higher MIB-1 labeling indices compared to the MIB-1 labeling indices of the non-recurrent tumors. Overall, 11 of the patients with RIM had multiple lesions and 8 cases developed recurrence (72.7%). RIM cases with multiple lesions had higher MIB-1 labeling indices compared to the MIB-1 labeling indices of cases with single lesions. Collectively, these data showed that the MIB-1 labeling index is as important for predicting RIM recurrences, as it is for predicting sporadic meningioma (SM) recurrences. RIMs should be treated more aggressively than SMs because of their greater malignant potential.

Asunto(s)

Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos; Irradiación Craneana/efectos adversos; Antígeno Ki-67/metabolismo; Meningioma/etiología; Recurrencia Local de Neoplasia/etiología; Neoplasias Inducidas por Radiación/etiología; Leucemia-Linfoma Linfoblástico de Células Precursoras/radioterapia; Adulto; Biomarcadores de Tumor/metabolismo; Terapia Combinada; Femenino; Humanos; Técnicas para Inmunoenzimas; Meningioma/metabolismo; Meningioma/patología; Recurrencia Local de Neoplasia/metabolismo; Recurrencia Local de Neoplasia/patología; Neoplasias Inducidas por Radiación/metabolismo; Neoplasias Inducidas por Radiación/patología; Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico; Leucemia-Linfoma Linfoblástico de Células Precursoras/patología; Pronóstico

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Irradiación Craneana / Antígeno Ki-67 / Leucemia-Linfoma Linfoblástico de Células Precursoras / Meningioma / Recurrencia Local de Neoplasia / Neoplasias Inducidas por Radiación Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans Idioma: En Revista: World J Surg Oncol Año: 2014 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

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