Hidden risk genes with high-order intragenic epistasis in Alzheimer's disease.

Sun, Jiya; Song, Fuhai; Wang, Jiajia; Han, Guangchun; Bai, Zhouxian; Xie, Bin; Feng, Xuemei; Jia, Jianping; Duan, Yong; Lei, Hongxing

Sun, Jiya; Song, Fuhai; Wang, Jiajia; Han, Guangchun; Bai, Zhouxian; Xie, Bin; Feng, Xuemei; Jia, Jianping; Duan, Yong; Lei, Hongxing.

Afiliación

Sun J; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China.
Song F; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China.
Wang J; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China.
Han G; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China.
Bai Z; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China.
Xie B; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China.
Feng X; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Jia J; Center of Alzheimer's disease, Beijing Institute for Brain Disorders, Beijing, China Department of Neurology, Xuanwu hospital, Beijing, China.
Duan Y; UC Davis Genome Center and Department of Biomedical Engineering, Davis, CA, USA.
Lei H; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China Center of Alzheimer's disease, Beijing Institute for Brain Disorders, Beijing, China UC Davis Genome Center and Department of Biomedical Engineering, Davis, CA, USA.

J Alzheimers Dis ; 41(4): 1039-56, 2014.

Article en En | MEDLINE | ID: mdl-24762948

Asunto(s)

Enfermedad de Alzheimer/genética; Epistasis Genética; Predisposición Genética a la Enfermedad/genética; Polimorfismo de Nucleótido Simple/genética; Anciano; Anciano de 80 o más Años; Apolipoproteínas E/genética; Proteínas Portadoras/genética; Fosfodiesterasas de Nucleótidos Cíclicos Tipo 1/genética; Femenino; Estudios de Asociación Genética; Humanos; Masculino; Proteínas de la Membrana/genética; Proteínas de Transporte de Membrana Mitocondrial/genética; Proteínas del Tejido Nervioso/genética; Proteínas Tirosina Fosfatasas no Receptoras/genética; Receptores de HFE/genética; Receptores de Mineralocorticoides/genética; Canal Liberador de Calcio Receptor de Rianodina/genética; Ubiquitina-Proteína Ligasas/genética

Palabras clave

Alzheimer's disease; generalized multifactor dimensionality reduction; genetic risk; high-order; intragenic epistasis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Epistasis Genética / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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