Effects of chebulic acid on advanced glycation endproducts-induced collagen cross-links.
Biol Pharm Bull
; 37(7): 1162-7, 2014.
Article
en En
| MEDLINE
| ID: mdl-24759763
Advanced glycation end-products (AGEs) have been implicated in the development of diabetic complications. We report the antiglycating activity of chebulic acid (CA), isolated from Terminalia chebula on breaking the cross-links of proteins induced by AGEs and inhibiting the formation of AGEs. Aminoguanidine (AG) reduced 50% of glycated bovine serum albumin (BSA) with glycolaldehyde (glycol-BSA)-induced cross-links of collagen at a concentration of 67.8 ± 2.5 mM, the level of CA required for exerting a similar antiglycating activity was 38.8 ± 0.5 µM. Also, the breaking activity on collagen cross-links induced by glycol-BSA was potent with CA (IC50=1.46 ± 0.05 mM), exhibiting 50-fold stronger breaking activity than with ALT-711, a well-known cross-link breaker (IC50=72.2 ± 2.4 mM). IC50 values of DPPH· scavenging activity for CA and ascorbic acid (AA) were 39.2 ± 4.9 and 19.0 ± 1.2 µg dry matter (DM) mL(-1), respectively, and ferric reducing and antioxidant power (FRAP) activities for CA and AA were 4.70 ± 0.06 and 11.4 ± 0.1 mmol/FeSO4·7H2O/g DM, respectively. The chelating activities of CA, AG and ALT711 on copper-catalyzed oxidation of AA were compared, and in increasing order, ALT-711 (IC50 of 1.92 ± 0.20 mM)
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Benzopiranos
/
Albúmina Sérica Bovina
/
Depuradores de Radicales Libres
/
Colágeno
/
Productos Finales de Glicación Avanzada
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Reactivos de Enlaces Cruzados
Idioma:
En
Revista:
Biol Pharm Bull
Asunto de la revista:
BIOQUIMICA
/
FARMACOLOGIA
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Japón
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Benzopiranos
/
Albúmina Sérica Bovina
/
Depuradores de Radicales Libres
/
Colágeno
/
Productos Finales de Glicación Avanzada
/
Reactivos de Enlaces Cruzados
Idioma:
En
Revista:
Biol Pharm Bull
Asunto de la revista:
BIOQUIMICA
/
FARMACOLOGIA
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Japón