Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes.

Cochrane, A R; Idziak, C; Kerr, W J; Mondal, B; Paterson, L C; Tuttle, T; Andersson, S; Nilsson, G N

Cochrane, A R; Idziak, C; Kerr, W J; Mondal, B; Paterson, L C; Tuttle, T; Andersson, S; Nilsson, G N.

Afiliación

Cochrane AR; Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK. w.kerr@strath.ac.uk.

Org Biomol Chem ; 12(22): 3598-603, 2014 Jun 14.

Article en En | MEDLINE | ID: mdl-24756541

RESUMEN

The use of alternative solvents in the iridium-catalysed hydrogen isotope exchange reaction with developing phosphine/NHC Ir(I) complexes has identified reaction media which are more widely applicable and industrially acceptable than the commonly employed chlorinated solvent, dichloromethane. Deuterium incorporation into a variety of substrates has proceeded to deliver high levels of labelling (and regioselectivity) in the presence of low catalyst loadings and over short reaction times. The preparative outputs have been complemented by DFT studies to explore ligand orientation, as well as solvent and substrate binding energies within the catalyst system.

Asunto(s)

Química Orgánica/métodos; Medición de Intercambio de Deuterio/métodos; Hidrógeno/química; Iridio/química; Anilidas/química; Catálisis; Conformación Molecular; Niclosamida/química; Solventes/química

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Orgánica / Medición de Intercambio de Deuterio / Hidrógeno / Iridio Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido

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