Your browser doesn't support javascript.
loading
Zinc oxide nanoparticles induce migration and adhesion of monocytes to endothelial cells and accelerate foam cell formation.
Suzuki, Yuka; Tada-Oikawa, Saeko; Ichihara, Gaku; Yabata, Masayuki; Izuoka, Kiyora; Suzuki, Masako; Sakai, Kiyoshi; Ichihara, Sahoko.
Afiliación
  • Suzuki Y; Graduate School of Regional Innovation Studies, Mie University, Tsu, Japan.
  • Tada-Oikawa S; Graduate School of Regional Innovation Studies, Mie University, Tsu, Japan.
  • Ichihara G; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Yabata M; Graduate School of Regional Innovation Studies, Mie University, Tsu, Japan.
  • Izuoka K; Graduate School of Regional Innovation Studies, Mie University, Tsu, Japan.
  • Suzuki M; Nagoya City Public Health Research Institute, Nagoya, Japan.
  • Sakai K; Nagoya City Public Health Research Institute, Nagoya, Japan.
  • Ichihara S; Graduate School of Regional Innovation Studies, Mie University, Tsu, Japan. Electronic address: saho@gene.mie-u.ac.jp.
Toxicol Appl Pharmacol ; 278(1): 16-25, 2014 Jul 01.
Article en En | MEDLINE | ID: mdl-24746987
Metal oxide nanoparticles are widely used in industry, cosmetics, and biomedicine. However, the effects of exposure to these nanoparticles on the cardiovascular system remain unknown. The present study investigated the effects of nanosized TiO2 and ZnO particles on the migration and adhesion of monocytes, which are essential processes in atherosclerogenesis, using an in vitro set-up of human umbilical vein endothelial cells (HUVECs) and human monocytic leukemia cells (THP-1). We also examined the effects of exposure to nanosized metal oxide particles on macrophage cholesterol uptake and foam cell formation. The 16-hour exposure to ZnO particles increased the level of monocyte chemotactic protein-1 (MCP-1) and induced the migration of THP-1 monocyte mediated by increased MCP-1. Exposure to ZnO particles also induced adhesion of THP-1 cells to HUVECs. Moreover, exposure to ZnO particles, but not TiO2 particles, upregulated the expression of membrane scavenger receptors of modified LDL and increased cholesterol uptake in THP-1 monocytes/macrophages. In the present study, we found that exposure to ZnO particles increased macrophage cholesterol uptake, which was mediated by an upregulation of membrane scavenger receptors of modified LDL. These results suggest that nanosized ZnO particles could potentially enhance atherosclerogenesis and accelerate foam cell formation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido de Zinc / Monocitos / Adhesión Celular / Movimiento Celular / Nanopartículas del Metal / Células Endoteliales de la Vena Umbilical Humana / Células Espumosas Límite: Humans Idioma: En Revista: Toxicol Appl Pharmacol Año: 2014 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido de Zinc / Monocitos / Adhesión Celular / Movimiento Celular / Nanopartículas del Metal / Células Endoteliales de la Vena Umbilical Humana / Células Espumosas Límite: Humans Idioma: En Revista: Toxicol Appl Pharmacol Año: 2014 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos