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Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil.
Nunes, Marcio R T; Palacios, Gustavo; Faria, Nuno Rodrigues; Sousa, Edivaldo Costa; Pantoja, Jamilla A; Rodrigues, Sueli G; Carvalho, Valéria L; Medeiros, Daniele B A; Savji, Nazir; Baele, Guy; Suchard, Marc A; Lemey, Philippe; Vasconcelos, Pedro F C; Lipkin, W Ian.
Afiliación
  • Nunes MR; Centro de Inovação Tecnológica, Instituto Evandro Chagas, Ananindeua, Brazil.
  • Palacios G; Center for Genomic Sciences, United States Army Medical Research Institute for Infectious Diseases, Frederick, Maryland, United States of America; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
  • Faria NR; Department of Zoology, University of Oxford, Oxford, United Kingdom.
  • Sousa EC; Centro de Inovação Tecnológica, Instituto Evandro Chagas, Ananindeua, Brazil.
  • Pantoja JA; Centro de Inovação Tecnológica, Instituto Evandro Chagas, Ananindeua, Brazil.
  • Rodrigues SG; Departamento de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Ananindeua, Brazil.
  • Carvalho VL; Departamento de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Ananindeua, Brazil.
  • Medeiros DB; Departamento de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Ananindeua, Brazil.
  • Savji N; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
  • Baele G; Department of Zoology, University of Oxford, Oxford, United Kingdom.
  • Suchard MA; Department of Biomathematics, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, California, United States of America; Department of Human Genetics, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, California, United States of A
  • Lemey P; Department of Zoology, University of Oxford, Oxford, United Kingdom.
  • Vasconcelos PF; Departamento de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Ananindeua, Brazil; Universidade do Estado do Pará, Belém, Pará, Brazil.
  • Lipkin WI; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
PLoS Negl Trop Dis ; 8(4): e2769, 2014 Apr.
Article en En | MEDLINE | ID: mdl-24743730
Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. For all three serotypes, we estimated that the introduction of new lineages occurred within 7 to 10-year intervals. New lineages were most likely to be imported from the Caribbean region to the North and Northeast regions of Brazil, and then to disperse at a rate of approximately 0.5 km/day. Joint statistical analysis of evolutionary, epidemiological and ecological data indicates that aerial transportation of humans and/or vector mosquitoes, rather than Aedes aegypti infestation rates or geographical distances, determine dengue virus spread in Brazil.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dengue / Virus del Dengue / Viaje en Avión Tipo de estudio: Risk_factors_studies Límite: Animals / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2014 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dengue / Virus del Dengue / Viaje en Avión Tipo de estudio: Risk_factors_studies Límite: Animals / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2014 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos