Your browser doesn't support javascript.
loading
Refractory hypercalcaemia secondary to parathyroid carcinoma: response to high-dose denosumab.
Karuppiah, Dharshini; Thanabalasingham, Gaya; Shine, Brian; Wang, Lai Mun; Sadler, Gregory P; Karavitaki, Niki; Grossman, Ashley B.
Afiliación
  • Karuppiah D; Departments of EndocrinologyChemical PathologyCellular PathologyEndocrine SurgeryOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
  • Thanabalasingham G; Departments of EndocrinologyChemical PathologyCellular PathologyEndocrine SurgeryOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
  • Shine B; Departments of EndocrinologyChemical PathologyCellular PathologyEndocrine SurgeryOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
  • Wang LM; Departments of EndocrinologyChemical PathologyCellular PathologyEndocrine SurgeryOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
  • Sadler GP; Departments of EndocrinologyChemical PathologyCellular PathologyEndocrine SurgeryOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
  • Karavitaki N; Departments of EndocrinologyChemical PathologyCellular PathologyEndocrine SurgeryOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
  • Grossman AB; Departments of EndocrinologyChemical PathologyCellular PathologyEndocrine SurgeryOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK ashley.grossman@ocdem.ox.ac.uk.
Eur J Endocrinol ; 171(1): K1-5, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24743399
OBJECTIVE: Hypercalcaemia is an important cause of increased morbidity and mortality in patients with parathyroid carcinoma. Surgical resection is the mainstay of treatment but, equally, managing hypercalcaemia is of paramount importance. At present, few therapies have been shown to be effective in the most severe cases. This report describes the efficacy of denosumab in a patient with parathyroid carcinoma when conventional therapies had been shown to be relatively ineffective.SUBJECT, METHODS AND RESULTS: A 50-year-old man presented with symptomatic hypercalcaemia 1 year after the surgery for his parathyroid carcinoma. Investigations revealed raised serum calcium and parathyroid hormone concentrations consistent with the recurrence of the disease. Imaging failed to localise any surgically remediable foci. Medical management with loop diuretics, calcimimetics and bisphosphonates failed to provide a sustained response. Denosumab, as a monthly injection, led to a gradual decrement in his peak calcium concentrations with the values now persistently below 3 mmol/l. CONCLUSIONS: Denosumab, a fully human MAB that binds to the 'receptor activator of nuclear factor κB ligand (RANKL)', was shown to have a profound effect in modulating malignant hypercalcaemia. This medication should be considered as an effective option in patients with refractory hypercalcaemia secondary to parathyroid carcinoma.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Paraneoplásicos / Neoplasias de las Paratiroides / Anticuerpos Monoclonales Humanizados / Hipercalcemia Límite: Humans / Male / Middle aged Idioma: En Revista: Eur J Endocrinol Asunto de la revista: ENDOCRINOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Paraneoplásicos / Neoplasias de las Paratiroides / Anticuerpos Monoclonales Humanizados / Hipercalcemia Límite: Humans / Male / Middle aged Idioma: En Revista: Eur J Endocrinol Asunto de la revista: ENDOCRINOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido