Enhancing proteasome-lnhibitor effect by functionalized gold nanoparticles.
J Biomed Nanotechnol
; 10(4): 717-23, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24734524
Colloidal gold nanoparticles intensify the anticancer response of the drug bortezomib, a proteasome inhibitor. Polyethylene glycol-coated gold nanoparticles and the drug show a synergistic effect in reducing the cell viability of prostate cancer cell line Du145. It was observed a significant cell viability reduction with bortezomib concentrations as low as 4 nM. The proteasome inhibitor alone had to be present at concentrations in the ranger of 120 nM to induce identical cytotoxicity response. These findings demonstrate that gold nanoparticles enhancing the permeation and retention (EPR) effect in Du145 cells and open the possibility to decrease multi-drug resistance (MDR). The in vitro results of functionalized gold nanoparticles, internalized by cancer cells, pave the way for a more efficient proteasome inhibitor delivery and release in adenocarcinoma cells.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Pirazinas
/
Ácidos Borónicos
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Nanopartículas del Metal
/
Inhibidores de Proteasoma
/
Oro
Límite:
Humans
/
Male
Idioma:
En
Revista:
J Biomed Nanotechnol
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Estados Unidos