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Prediction and prevention of the first psychotic episode: new directions and opportunities.
Piras, Sara; Casu, Gianluca; Casu, Maria Antonietta; Orrù, Alessandro; Ruiu, Stefania; Pilleri, Antonio; Manca, Gabriella; Marchese, Giorgio.
Afiliación
  • Piras S; National Research Council, institute of Translational Pharmacology, Strategic Operating Unit of Cagliari, Cagliari, Italy.
  • Casu G; National Research Council, institute of Translational Pharmacology, Strategic Operating Unit of Cagliari, Cagliari, Italy.
  • Casu MA; National Research Council, institute of Translational Pharmacology, Strategic Operating Unit of Cagliari, Cagliari, Italy.
  • Orrù A; National Research Council, institute of Translational Pharmacology, Strategic Operating Unit of Cagliari, Cagliari, Italy.
  • Ruiu S; National Research Council, institute of Translational Pharmacology, Strategic Operating Unit of Cagliari, Cagliari, Italy.
  • Pilleri A; National Research Council, institute of Translational Pharmacology, Strategic Operating Unit of Cagliari, Cagliari, Italy.
  • Manca G; National Research Council, institute of Translational Pharmacology, Strategic Operating Unit of Cagliari, Cagliari, Italy.
  • Marchese G; National Research Council, institute of Translational Pharmacology, Strategic Operating Unit of Cagliari, Cagliari, Italy.
Ther Clin Risk Manag ; 10: 241-53, 2014.
Article en En | MEDLINE | ID: mdl-24729711
In the last few decades, substantial research has focused on the possibility of early detection and prevention of the first psychotic episode in young individuals at risk of developing this mental disturbance; however, unresolved clinical and ethical issues still call for further investigations. New perspectives and opportunities may come from the identification of selective psychopathological and instrumental markers linking the appearance of subtle psychotic symptoms with the clinical outcome of specific mental pathologies. Furthermore, empirically derived algorithms and risk staging models should facilitate the identification of targeted prevention therapies, possibly improving the efficacy of well-tolerated therapeutic approaches, such as psychological interventions and natural compound supplementations. To date, the collected evidence on the efficacy and tolerability of pharmacological prevention therapies raises more doubts than hopes. A very early detection of risk and appropriate symptomatic pattern classifications may provide a chance to better match prevention strategies with the development of psychosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies / Screening_studies Aspecto: Ethics Idioma: En Revista: Ther Clin Risk Manag Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies / Screening_studies Aspecto: Ethics Idioma: En Revista: Ther Clin Risk Manag Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Nueva Zelanda