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Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.
Granados-Principal, Sergio; El-Azem, Nuri; Pamplona, Reinald; Ramirez-Tortosa, Cesar; Pulido-Moran, Mario; Vera-Ramirez, Laura; Quiles, Jose L; Sanchez-Rovira, Pedro; Naudí, Alba; Portero-Otin, Manuel; Perez-Lopez, Patricia; Ramirez-Tortosa, Mcarmen.
Afiliación
  • Granados-Principal S; Department of Biochemistry and Molecular Biology II, Biomedical Research Center, Granada, Spain; "José Mataix" Institute of Nutrition and Food Technology, Biomedical Research Center, Granada, Spain.
  • El-Azem N; Department of Biochemistry and Molecular Biology II, Biomedical Research Center, Granada, Spain; "José Mataix" Institute of Nutrition and Food Technology, Biomedical Research Center, Granada, Spain.
  • Pamplona R; Department of Experimental Medicine, Faculty of Medicine, University of Lleida-IRB, Lleida, Spain.
  • Ramirez-Tortosa C; Pathological Anatomy Service, Jaen City Hospital, Jaen, Spain.
  • Pulido-Moran M; Department of Biochemistry and Molecular Biology II, Biomedical Research Center, Granada, Spain; "José Mataix" Institute of Nutrition and Food Technology, Biomedical Research Center, Granada, Spain.
  • Vera-Ramirez L; GENYO, Granada, Spain.
  • Quiles JL; "José Mataix" Institute of Nutrition and Food Technology, Biomedical Research Center, Granada, Spain; Department of Physiology, Biomedical Research Center, Granada, Spain.
  • Sanchez-Rovira P; Oncology Service, Jaen City Hospital, Jaen, Spain.
  • Naudí A; Department of Experimental Medicine, Faculty of Medicine, University of Lleida-IRB, Lleida, Spain.
  • Portero-Otin M; Department of Experimental Medicine, Faculty of Medicine, University of Lleida-IRB, Lleida, Spain.
  • Perez-Lopez P; "José Mataix" Institute of Nutrition and Food Technology, Biomedical Research Center, Granada, Spain; Department of Physiology, Biomedical Research Center, Granada, Spain.
  • Ramirez-Tortosa M; Department of Biochemistry and Molecular Biology II, Biomedical Research Center, Granada, Spain; "José Mataix" Institute of Nutrition and Food Technology, Biomedical Research Center, Granada, Spain. Electronic address: mramirez@ugr.es.
Biochem Pharmacol ; 90(1): 25-33, 2014 Jul 01.
Article en En | MEDLINE | ID: mdl-24727461
Oxidative stress is involved in several processes including cancer, aging and cardiovascular disease, and has been shown to potentiate the therapeutic effect of drugs such as doxorubicin. Doxorubicin causes significant cardiotoxicity characterized by marked increases in oxidative stress and mitochondrial dysfunction. Herein, we investigate whether doxorubicin-associated chronic cardiac toxicity can be ameliorated with the antioxidant hydroxytyrosol in rats with breast cancer. Thirty-six rats bearing breast tumors induced chemically were divided into 4 groups: control, hydroxytyrosol (0.5mg/kg, 5days/week), doxorubicin (1mg/kg/week), and doxorubicin plus hydroxytyrosol. Cardiac disturbances at the cellular and mitochondrial level, mitochondrial electron transport chain complexes I-IV and apoptosis-inducing factor, and oxidative stress markers have been analyzed. Hydroxytyrosol improved the cardiac disturbances enhanced by doxorubicin by significantly reducing the percentage of altered mitochondria and oxidative damage. These results suggest that hydroxytyrosol improve the mitochondrial electron transport chain. This study demonstrates that hydroxytyrosol protect rat heart damage provoked by doxorubicin decreasing oxidative damage and mitochondrial alterations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcohol Feniletílico / Neoplasias Mamarias Animales / Estrés Oxidativo / Cardiopatías / Mitocondrias Cardíacas Límite: Animals Idioma: En Revista: Biochem Pharmacol Año: 2014 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcohol Feniletílico / Neoplasias Mamarias Animales / Estrés Oxidativo / Cardiopatías / Mitocondrias Cardíacas Límite: Animals Idioma: En Revista: Biochem Pharmacol Año: 2014 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido