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Exploring bacterial epigenomics in the next-generation sequencing era: a new approach for an emerging frontier.
Chen, Poyin; Jeannotte, Richard; Weimer, Bart C.
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  • Chen P; Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, USA; Universidad de Tarapacá, Avenida General Velásquez N°1775, Arica, Chile.
  • Jeannotte R; Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, USA; Universidad de Tarapacá, Avenida General Velásquez N°1775, Arica, Chile; Facultad de Ciencias, Universidad de Tarapacá, Arica, Chile.
  • Weimer BC; Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, USA; Universidad de Tarapacá, Avenida General Velásquez N°1775, Arica, Chile. Electronic address: bcweimer@ucdavis.edu.
Trends Microbiol ; 22(5): 292-300, 2014 May.
Article en En | MEDLINE | ID: mdl-24725482
Epigenetics has an important role for the success of foodborne pathogen persistence in diverse host niches. Substantial challenges exist in determining DNA methylation to situation-specific phenotypic traits. DNA modification, mediated by restriction-modification systems, functions as an immune response against antagonistic external DNA, and bacteriophage-acquired methyltransferases (MTase) and orphan MTases - those lacking the cognate restriction endonuclease - facilitate evolution of new phenotypes via gene expression modulation via DNA and RNA modifications, including methylation and phosphorothioation. Recent establishment of large-scale genome sequencing projects will result in a significant increase in genome availability that will lead to new demands for data analysis including new predictive bioinformatics approaches that can be verified with traditional scientific rigor. Sequencing technologies that detect modification coupled with mass spectrometry to discover new adducts is a powerful tactic to study bacterial epigenetics, which is poised to make novel and far-reaching discoveries that link biological significance and the bacterial epigenome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectrometría de Masas / Bacterias / Secuenciación de Nucleótidos de Alto Rendimiento / Epigenómica Idioma: En Revista: Trends Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectrometría de Masas / Bacterias / Secuenciación de Nucleótidos de Alto Rendimiento / Epigenómica Idioma: En Revista: Trends Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Reino Unido