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High prolactin levels are independently associated with damage accrual in systemic lupus erythematosus patients.
Ugarte-Gil, M F; Gamboa-Cárdenas, R V; Zevallos, F; Medina, M; Cucho-Venegas, J M; Perich-Campos, R A; Alfaro-Lozano, J L; Rodriguez-Bellido, Z; Alarcón, G S; Pastor-Asurza, C A.
Afiliación
  • Ugarte-Gil MF; Servicio de Reumatología, Hospital Nacional Guillermo Almenara Irigoyen, Perú Universidad Científica del Sur, Perú manuel_ugarte@yahoo.com.
  • Gamboa-Cárdenas RV; Servicio de Reumatología, Hospital Nacional Guillermo Almenara Irigoyen, Perú
  • Zevallos F; Servicio de Reumatología, Hospital Nacional Guillermo Almenara Irigoyen, Perú
  • Medina M; Servicio de Reumatología, Hospital Nacional Guillermo Almenara Irigoyen, Perú
  • Cucho-Venegas JM; Servicio de Reumatología, Hospital Nacional Guillermo Almenara Irigoyen, Perú
  • Perich-Campos RA; Servicio de Reumatología, Hospital Nacional Guillermo Almenara Irigoyen, Perú Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Alfaro-Lozano JL; Servicio de Reumatología, Hospital Nacional Guillermo Almenara Irigoyen, Perú
  • Rodriguez-Bellido Z; Servicio de Reumatología, Hospital Nacional Guillermo Almenara Irigoyen, Perú Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Alarcón GS; Department of Medicine, Division of Clinical Immunology and Rheumatology, School of Medicine, The University of Alabama at Birmingham, USA.
  • Pastor-Asurza CA; Servicio de Reumatología, Hospital Nacional Guillermo Almenara Irigoyen, Perú Universidad Nacional Mayor de San Marcos, Lima, Perú
Lupus ; 23(10): 969-74, 2014 Sep.
Article en En | MEDLINE | ID: mdl-24718588
OBJECTIVE: to determine whether prolactin levels are independently associated with disease damage in systemic lupus erythematosus (SLE) patients. METHODS: these cross-sectional analyses were conducted in SLE patient members of the Almenara Lupus Cohort who were seen between January 2012 and June 2013. Disease damage was ascertained with the System Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI). Prolactin was measured in ng/ml. The association between prolactin levels and the SDI (total and its domains) was evaluated using Spearman's correlation. Subsequently, adjusted Poisson regression models were performed to evaluate these associations. RESULTS: 160 patients were included. 147 (91.9%) were female; their median age at diagnosis was 33.4 (interquartile range (IQR): 26.0-44.3) years; their disease duration was 5.5 (IQR: 2.6-9.7) years. The median prolactin value was 16.8 (IQR: 11.8-24.5) ng/ml. After adjusting for confounders in the Poisson regression model the estimated rate ratios (RR) and 95% confidence interval (CI) for each 10 ng/ml increment of prolactin were 1.13 (95% CI 1.60-1.20, p<0.001) for the total SDI score, 1.15 (1.03-1.28, p=0.003) for the renal domain and 1.41 (1.11-1.79, p=0.003) for the cardiac/peripheral vascular domains. CONCLUSIONS: there was a positive association between prolactin levels and the SDI (overall and its renal and cardiac/peripheral vascular domains), independently of other well-known risk factors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prolactina / Hiperprolactinemia / Lupus Eritematoso Sistémico Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: America do sul / Peru Idioma: En Revista: Lupus Asunto de la revista: REUMATOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prolactina / Hiperprolactinemia / Lupus Eritematoso Sistémico Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: America do sul / Peru Idioma: En Revista: Lupus Asunto de la revista: REUMATOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido