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Epigenetics and migraine; complex mitochondrial interactions contributing to disease susceptibility.
Roos-Araujo, Deidré; Stuart, Shani; Lea, Rod A; Haupt, Larisa M; Griffiths, Lyn R.
Afiliación
  • Roos-Araujo D; Genomics Research Centre, Institute for Biomedical Health and Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia.
  • Stuart S; Genomics Research Centre, Institute for Biomedical Health and Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia.
  • Lea RA; Genomics Research Centre, Institute for Biomedical Health and Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia.
  • Haupt LM; Genomics Research Centre, Institute for Biomedical Health and Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia.
  • Griffiths LR; Genomics Research Centre, Institute for Biomedical Health and Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia. Electronic address: lyn.griffiths@qut.edu.au.
Gene ; 543(1): 1-7, 2014 Jun 10.
Article en En | MEDLINE | ID: mdl-24704026
Migraine is a common neurological disorder classified by the World Health Organisation (WHO) as one of the top twenty most debilitating diseases in the developed world. Current therapies are only effective for a proportion of sufferers and new therapeutic targets are desperately needed to alleviate this burden. Recently the role of epigenetics in the development of many complex diseases including migraine has become an emerging topic. By understanding the importance of acetylation, methylation and other epigenetic modifications, it then follows that this modification process is a potential target to manipulate epigenetic status with the goal of treating disease. Bisulphite sequencing and methylated DNA immunoprecipitation have been used to demonstrate the presence of methylated cytosines in the human D-loop of mitochondrial DNA (mtDNA), proving that the mitochondrial genome is methylated. For the first time, it has been shown that there is a difference in mtDNA epigenetic status between healthy controls and those with disease, especially for neurodegenerative and age related conditions. Given co-morbidities with migraine and the suggestive link between mitochondrial dysfunction and the lowered threshold for triggering a migraine attack, mitochondrial methylation may be a new avenue to pursue. Creative thinking and new approaches are needed to solve complex problems and a systems biology approach, where multiple layers of information are integrated is becoming more important in complex disease modelling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Epigénesis Genética / Epistasis Genética / Trastornos Migrañosos / Mitocondrias Límite: Humans Idioma: En Revista: Gene Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Epigénesis Genética / Epistasis Genética / Trastornos Migrañosos / Mitocondrias Límite: Humans Idioma: En Revista: Gene Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos