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A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia.
Gröschel, Stefan; Sanders, Mathijs A; Hoogenboezem, Remco; de Wit, Elzo; Bouwman, Britta A M; Erpelinck, Claudia; van der Velden, Vincent H J; Havermans, Marije; Avellino, Roberto; van Lom, Kirsten; Rombouts, Elwin J; van Duin, Mark; Döhner, Konstanze; Beverloo, H Berna; Bradner, James E; Döhner, Hartmut; Löwenberg, Bob; Valk, Peter J M; Bindels, Eric M J; de Laat, Wouter; Delwel, Ruud.
Afiliación
  • Gröschel S; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands; Department of Internal Medicine III, Ulm University Hospital, 89081 Ulm, Germany.
  • Sanders MA; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands.
  • Hoogenboezem R; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands.
  • de Wit E; Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, 3584 CT, the Netherlands.
  • Bouwman BAM; Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, 3584 CT, the Netherlands.
  • Erpelinck C; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands.
  • van der Velden VHJ; Department of Immunology, Erasmus University Medical Center, Rotterdam, 3015 CN, the Netherlands.
  • Havermans M; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands.
  • Avellino R; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands.
  • van Lom K; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands.
  • Rombouts EJ; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands.
  • van Duin M; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands.
  • Döhner K; Department of Internal Medicine III, Ulm University Hospital, 89081 Ulm, Germany.
  • Beverloo HB; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands; Dutch Working Group on Hemato-Oncologic Genome Diagnostics, Rotterdam, 3015 GE, the Netherlands.
  • Bradner JE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Döhner H; Department of Internal Medicine III, Ulm University Hospital, 89081 Ulm, Germany.
  • Löwenberg B; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands.
  • Valk PJM; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands.
  • Bindels EMJ; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands.
  • de Laat W; Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, 3584 CT, the Netherlands.
  • Delwel R; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands. Electronic address: h.delwel@erasmusmc.nl.
Cell ; 157(2): 369-381, 2014 Apr 10.
Article en En | MEDLINE | ID: mdl-24703711
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Síndromes Mielodisplásicos / Cromosomas Humanos Par 3 / Proto-Oncogenes / Leucemia Mieloide Aguda / Regulación Neoplásica de la Expresión Génica / Elementos de Facilitación Genéticos / Proteínas de Unión al ADN / Factor de Transcripción GATA2 Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Cell Año: 2014 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Síndromes Mielodisplásicos / Cromosomas Humanos Par 3 / Proto-Oncogenes / Leucemia Mieloide Aguda / Regulación Neoplásica de la Expresión Génica / Elementos de Facilitación Genéticos / Proteínas de Unión al ADN / Factor de Transcripción GATA2 Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Cell Año: 2014 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos