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Soy-dairy protein blend and whey protein ingestion after resistance exercise increases amino acid transport and transporter expression in human skeletal muscle.
Reidy, P T; Walker, D K; Dickinson, J M; Gundermann, D M; Drummond, M J; Timmerman, K L; Cope, M B; Mukherjea, R; Jennings, K; Volpi, E; Rasmussen, B B.
Afiliación
  • Reidy PT; Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas; Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas;
  • Walker DK; Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas; Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas;
  • Dickinson JM; Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas; Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas;
  • Gundermann DM; Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas; Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas;
  • Drummond MJ; Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas;
  • Timmerman KL; Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas;
  • Cope MB; DuPont Nutrition & Health, St. Louis, Missouri.
  • Mukherjea R; DuPont Nutrition & Health, St. Louis, Missouri.
  • Jennings K; Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas; and.
  • Volpi E; Department of Internal Medicine/Geriatrics, University of Texas Medical Branch, Galveston, Texas; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas;
  • Rasmussen BB; Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas; Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas; blrasmus@utmb.edu.
J Appl Physiol (1985) ; 116(11): 1353-64, 2014 Jun 01.
Article en En | MEDLINE | ID: mdl-24699854
Increasing amino acid availability (via infusion or ingestion) at rest or postexercise enhances amino acid transport into human skeletal muscle. It is unknown whether alterations in amino acid availability, from ingesting different dietary proteins, can enhance amino acid transport rates and amino acid transporter (AAT) mRNA expression. We hypothesized that the prolonged hyperaminoacidemia from ingesting a blend of proteins with different digestion rates postexercise would enhance amino acid transport into muscle and AAT expression compared with the ingestion of a rapidly digested protein. In a double-blind, randomized clinical trial, we studied 16 young adults at rest and after acute resistance exercise coupled with postexercise (1 h) ingestion of either a (soy-dairy) protein blend or whey protein. Phenylalanine net balance and transport rate into skeletal muscle were measured using stable isotopic methods in combination with femoral arteriovenous blood sampling and muscle biopsies obtained at rest and 3 and 5 h postexercise. Phenylalanine transport into muscle and mRNA expression of select AATs [system L amino acid transporter 1/solute-linked carrier (SLC) 7A5, CD98/SLC3A2, system A amino acid transporter 2/SLC38A2, proton-assisted amino acid transporter 1/SLC36A1, cationic amino acid transporter 1/SLC7A1] increased to a similar extent in both groups (P < 0.05). However, the ingestion of the protein blend resulted in a prolonged and positive net phenylalanine balance during postexercise recovery compared with whey protein (P < 0.05). Postexercise myofibrillar protein synthesis increased similarly between groups. We conclude that, while both protein sources enhanced postexercise AAT expression, transport into muscle, and myofibrillar protein synthesis, postexercise ingestion of a protein blend results in a slightly prolonged net amino acid balance across the leg compared with whey protein.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas en la Dieta / Músculo Esquelético / Proteínas de Soja / Sistemas de Transporte de Aminoácidos / Entrenamiento de Fuerza / Aminoácidos / Proteínas de la Leche Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male Idioma: En Revista: J Appl Physiol (1985) Asunto de la revista: FISIOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas en la Dieta / Músculo Esquelético / Proteínas de Soja / Sistemas de Transporte de Aminoácidos / Entrenamiento de Fuerza / Aminoácidos / Proteínas de la Leche Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male Idioma: En Revista: J Appl Physiol (1985) Asunto de la revista: FISIOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos