Stem cell therapy for cardiovascular disorders - our clinical experience.
J Stem Cells Regen Med
; 7(2): 96, 2011.
Article
en En
| MEDLINE
| ID: mdl-24693183
BACKGROUND: Autologous Bone Marrow stem Cell transplantation is a viable therapeutic option for patients with end stage heart failure due to cardiomyopathy of varied etiology as there are only limited treatment options other than cardiac transplantation. The rationale behind the application of stem cells in these patients include Stem cells directly replace the affected cells by differentiation into the damaged cell typeStem cells also exert Paracrine effects by secretion of growth factors (VGEF,FGF-1)to stimulate local cell growthIn addition to the above, stem cells release signaling factors which recruit stem cells from elsewhere by modulating the immune system. MATERIALS & METHODS: In this presentation we describe our study on a series of 13 patients who received isolated and expanded CD 34 cells from the bone marrow. Seven had ischemic dysfunction, three had dilated cardiomyopathy and three had primary pulmonary hypertension. Five patients received the stem cells via intracoronary injection, three directly into the myocardium and three intrapulmonary. RESULTS: All patients showed functional improvement of the myocardium recorded by non-invasive investigations and improvement in the quality of life. Follow up period ranged from 6 months to 2 years. CONCLUSION: Our experience with bone marrow derived stem cells in patients with cardiomyopathy has been encouraging. More studies are planned in the future.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Aspecto:
Patient_preference
Idioma:
En
Revista:
J Stem Cells Regen Med
Año:
2011
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
India