[An overview of glycoconjugates for cancer targeting therapy and diagnosis].
Yao Xue Xue Bao
; 48(12): 1763-70, 2013 Dec.
Article
en Zh
| MEDLINE
| ID: mdl-24689232
Because of the changed metabolic behaviors of cancer cells, tumor cells uptake a corresponding larger amount of glucose in physiological condition when compared with normal cells. And they were prone to metabolize glucose for generating energy in anaerobic glycolysis ways in order to grow quickly. Anaerobic glycolysis consumes more glucose than aerobic way when the same amount of energy is obtained, which also results in large demand of glucose in tumor cells. This review briefly describes therapy methods related to characteristic mentioned above, and summarizes the research progress of drugs, diagnostic reagents and carriers conjugated with glucose, glucose derivatives or other kinds of sugars for cancer targeting. Furthermore, typically relative research reports from 2012 till now were listed and analyzed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glicoconjugados
/
Glucosa
/
Neoplasias
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2013
Tipo del documento:
Article
Pais de publicación:
China