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Assessment of Mycobacterium tuberculosis pantothenate kinase vulnerability through target knockdown and mechanistically diverse inhibitors.
Reddy, B K Kishore; Landge, Sudhir; Ravishankar, Sudha; Patil, Vikas; Shinde, Vikas; Tantry, Subramanyam; Kale, Manoj; Raichurkar, Anandkumar; Menasinakai, Sreenivasaiah; Mudugal, Naina Vinay; Ambady, Anisha; Ghosh, Anirban; Tunduguru, Ragadeepthi; Kaur, Parvinder; Singh, Ragini; Kumar, Naveen; Bharath, Sowmya; Sundaram, Aishwarya; Bhat, Jyothi; Sambandamurthy, Vasan K; Björkelid, Christofer; Jones, T Alwyn; Das, Kaveri; Bandodkar, Balachandra; Malolanarasimhan, Krishnan; Mukherjee, Kakoli; Ramachandran, Vasanthi.
Afiliación
  • Reddy BK; Department of Chemistry, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Landge S; Department of Chemistry, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Ravishankar S; Department of Bioscience, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Patil V; Department of Chemistry, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Shinde V; Department of Chemistry, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Tantry S; Department of Chemistry, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Kale M; Department of Chemistry, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Raichurkar A; Department of Chemistry, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Menasinakai S; Department of Chemistry, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Mudugal NV; Department of Bioscience, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Ambady A; Department of Bioscience, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Ghosh A; Department of Bioscience, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Tunduguru R; Department of Bioscience, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Kaur P; Department of Bioscience, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Singh R; Cellworks Research India Pvt. Ltd., Bangalore, India.
  • Kumar N; Department of DMPK and Animal Sciences, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Bharath S; Department of DMPK and Animal Sciences, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Sundaram A; Department of Bioscience, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Bhat J; Department of Bioscience, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Sambandamurthy VK; Department of Bioscience, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Björkelid C; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
  • Jones TA; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
  • Das K; Department of Bioscience, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Bandodkar B; Department of Chemistry, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Malolanarasimhan K; Department of Chemistry, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Mukherjee K; Department of Bioscience, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India.
  • Ramachandran V; Department of Bioscience, iMED infection, AstraZeneca India Pvt. Ltd., Bangalore, India vasanthi.ramachandran@astrazeneca.com.
Antimicrob Agents Chemother ; 58(6): 3312-26, 2014 Jun.
Article en En | MEDLINE | ID: mdl-24687493

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfotransferasas (Aceptor de Grupo Alcohol) / Inhibidores Enzimáticos / Mycobacterium tuberculosis / Antituberculosos Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2014 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfotransferasas (Aceptor de Grupo Alcohol) / Inhibidores Enzimáticos / Mycobacterium tuberculosis / Antituberculosos Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2014 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos