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Census 2: isobaric labeling data analysis.
Park, Sung Kyu Robin; Aslanian, Aaron; McClatchy, Daniel B; Han, Xuemei; Shah, Harshil; Singh, Meha; Rauniyar, Navin; Moresco, James J; Pinto, Antonio F M; Diedrich, Jolene K; Delahunty, Claire; Yates, John R.
Afiliación
  • Park SK; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Aslanian A; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • McClatchy DB; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Han X; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Shah H; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Singh M; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Rauniyar N; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Moresco JJ; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Pinto AF; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Diedrich JK; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Delahunty C; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Yates JR; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Bioinformatics ; 30(15): 2208-9, 2014 Aug 01.
Article en En | MEDLINE | ID: mdl-24681903
MOTIVATION: We introduce Census 2, an update of a mass spectrometry data analysis tool for peptide/protein quantification. New features for analysis of isobaric labeling, such as Tandem Mass Tag (TMT) or Isobaric Tags for Relative and Absolute Quantification (iTRAQ), have been added in this version, including a reporter ion impurity correction, a reporter ion intensity threshold filter and an option for weighted normalization to correct mixing errors. TMT/iTRAQ analysis can be performed on experiments using HCD (High Energy Collision Dissociation) only, CID (Collision Induced Dissociation)/HCD (High Energy Collision Dissociation) dual scans or HCD triple-stage mass spectrometry data. To improve measurement accuracy, we implemented weighted normalization, multiple tandem spectral approach, impurity correction and dynamic intensity threshold features. AVAILABILITY AND IMPLEMENTATION: Census 2 supports multiple input file formats including MS1/MS2, DTASelect, mzXML and pepXML. It requires JAVA version 6 or later to run. Free download of Census 2 for academic users is available at http://fields.scripps.edu/census/index.php. CONTACT: jyates@scripps.edu SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectrometría de Masas / Estadística como Asunto / Proteómica Límite: Animals Idioma: En Revista: Bioinformatics Asunto de la revista: INFORMATICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectrometría de Masas / Estadística como Asunto / Proteómica Límite: Animals Idioma: En Revista: Bioinformatics Asunto de la revista: INFORMATICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido