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Metabolic interactions between vitamin A and conjugated linoleic acid.
Carta, Gianfranca; Murru, Elisabetta; Cordeddu, Lina; Ortiz, Berenice; Giordano, Elena; Belury, Martha A; Quadro, Loredana; Banni, Sebastiano.
Afiliación
  • Carta G; Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554, km. 4500, Monserrato, Cagliari 09042, Italy. giacarta28@hotmail.com.
  • Murru E; Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554, km. 4500, Monserrato, Cagliari 09042, Italy. m.elisabetta.murru@gmail.com.
  • Cordeddu L; Department of Bioscience and Nutrition, Karolinska Institute, Stockholm 141 83, Sweden. lina_c@hotmail.it.
  • Ortiz B; Gerstner Sloan-Kettering Graduate School in Biomedical Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. OrtizB@mskcc.org.
  • Giordano E; Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM + CSIC, Madrid 28049, Spain. elen79@yahoo.it.
  • Belury MA; Department of Human Nutrition, Ohio State University, Columbus, OH 43210, USA. belury.1@osu.edu.
  • Quadro L; Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA. quadro@AESOP.Rutgers.edu.
  • Banni S; Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554, km. 4500, Monserrato, Cagliari 09042, Italy. banni@unica.it.
Nutrients ; 6(3): 1262-72, 2014 Mar 24.
Article en En | MEDLINE | ID: mdl-24667133
Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner. Dietary conjugated linoleic acid (CLA) is a fatty acid with a conjugated diene structure that is found in low concentrations in ruminant products and available as a nutritional supplement. CLA has been shown to increase tissue levels of retinol (vitamin A alcohol) and its sole specific circulating carrier protein retinol-binding protein (RBP or RBP4). However, the precise mechanism of this action has not been elucidated yet. Here, we provide a summary of the current knowledge in this specific area of research and speculate that retinol and CLA may compete for catabolic pathways modulated by the activity of PPAR-α and RXR heterodimer. We also present preliminary data that may position PPAR-α at the crossroads between the metabolism of lipids and vitamin A.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina A / Ácidos Linoleicos Conjugados Límite: Animals / Humans Idioma: En Revista: Nutrients Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina A / Ácidos Linoleicos Conjugados Límite: Animals / Humans Idioma: En Revista: Nutrients Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza