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RUNX2 is overexpressed in melanoma cells and mediates their migration and invasion.
Boregowda, Rajeev K; Olabisi, Oyenike O; Abushahba, Walid; Jeong, Byeong-Seon; Haenssen, Keneshia K; Chen, Wenjin; Chekmareva, Marina; Lasfar, Ahmed; Foran, David J; Goydos, James S; Cohen-Solal, Karine A.
Afiliación
  • Boregowda RK; Rutgers Cancer Institute of New Jersey, Department of Medicine, Division of Medical Oncology - Rutgers, The State University of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
  • Olabisi OO; Rutgers Cancer Institute of New Jersey, Department of Medicine, Division of Medical Oncology - Rutgers, The State University of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
  • Abushahba W; Rutgers Cancer Institute of New Jersey, Department of Medicine, Division of Medical Oncology - Rutgers, The State University of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
  • Jeong BS; Rutgers Cancer Institute of New Jersey, Department of Surgery, Division of Surgical Oncology, Rutgers, The State University of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
  • Haenssen KK; Rutgers Cancer Institute of New Jersey, Department of Surgery, Division of Surgical Oncology, Rutgers, The State University of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
  • Chen W; Center for Biomedical Imaging & Informatics - Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
  • Chekmareva M; Rutgers Cancer Institute of New Jersey - Department of Pathology and Laboratory Medicine, Robert Wood Johnson University Hospital, 1 RWJ Place, New Brunswick, NJ 08901, USA.
  • Lasfar A; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.
  • Foran DJ; Center for Biomedical Imaging & Informatics - Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
  • Goydos JS; Rutgers Cancer Institute of New Jersey, Department of Surgery, Division of Surgical Oncology, Rutgers, The State University of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
  • Cohen-Solal KA; Rutgers Cancer Institute of New Jersey, Department of Medicine, Division of Medical Oncology - Rutgers, The State University of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA. Electronic address: cohenska@cinj.rutgers.edu.
Cancer Lett ; 348(1-2): 61-70, 2014 Jun 28.
Article en En | MEDLINE | ID: mdl-24657655
In the present study, we investigated the role of the transcription factor RUNX2 in melanomagenesis. We demonstrated that the expression of transcriptionally active RUNX2 was increased in melanoma cell lines as compared with human melanocytes. Using a melanoma tissue microarray, we showed that RUNX2 levels were higher in melanoma cells as compared with nevic melanocytes. RUNX2 knockdown in melanoma cell lines significantly decreased Focal Adhesion Kinase expression, and inhibited their cell growth, migration and invasion ability. Finally, the pro-hormone cholecalciferol reduced RUNX2 transcriptional activity and decreased migration of melanoma cells, further suggesting a role of RUNX2 in melanoma cell migration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Movimiento Celular / Subunidad alfa 1 del Factor de Unión al Sitio Principal / Melanoma Límite: Humans Idioma: En Revista: Cancer Lett Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Movimiento Celular / Subunidad alfa 1 del Factor de Unión al Sitio Principal / Melanoma Límite: Humans Idioma: En Revista: Cancer Lett Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda