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Association between maternal inflammatory bowel disease and adverse perinatal outcomes.
Getahun, D; Fassett, M J; Longstreth, G F; Koebnick, C; Langer-Gould, A M; Strickland, D; Jacobsen, S J.
Afiliación
  • Getahun D; 1] Department of Research & Evaluation, Kaiser Permanente Southern California Medical Group, Pasadena, CA, USA [2] Department of Obstetrics and Gynecology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
  • Fassett MJ; Department of Maternal-Fetal Medicine, West Los Angeles Medical Center, Kaiser Permanente Southern California Medical Group, Pasadena, CA, USA.
  • Longstreth GF; Department of Research & Evaluation, Kaiser Permanente Southern California Medical Group, Pasadena, CA, USA.
  • Koebnick C; Department of Research & Evaluation, Kaiser Permanente Southern California Medical Group, Pasadena, CA, USA.
  • Langer-Gould AM; Department of Research & Evaluation, Kaiser Permanente Southern California Medical Group, Pasadena, CA, USA.
  • Strickland D; Department of Research & Evaluation, Kaiser Permanente Southern California Medical Group, Pasadena, CA, USA.
  • Jacobsen SJ; Department of Research & Evaluation, Kaiser Permanente Southern California Medical Group, Pasadena, CA, USA.
J Perinatol ; 34(6): 435-40, 2014 Jun.
Article en En | MEDLINE | ID: mdl-24651735
OBJECTIVE: To examine whether inflammatory bowel disease (IBD) is associated with ischemic/inflammatory conditions during pregnancy. STUDY DESIGN: A retrospective cohort study using the 2000 to 2012 Kaiser Permanente Southern California maternally-linked medical records (n=395 781). The two major subtypes of IBD, ulcerative colitis and Crohn's diseases were studied. Adjusted odds ratios (ORs) were used to quantify the associations. RESULT: A pregnancy complicated by IBD was associated with increased incidence of small-for-gestational age birth (OR=1.46, 95% confidence interval (CI)=1.14 to 1.88), spontaneous preterm birth (OR=1.32, 95% CI=1.00 to 1.76) and preterm premature rupture of membranes (OR=1.95, 95% CI=1.26 to 3.02). Further stratifying by IBD subtypes, only ulcerative colitis was significantly associated with increased incidence of ischemic placental disease, spontaneous preterm birth and preterm premature rupture of membranes. CONCLUSION: The findings underscore the potential impact of maternal IBD on adverse perinatal outcomes. Clinicians should be aware that the association between IBD and adverse perinatal outcome varies by IBD subtypes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Resultado del Embarazo / Colitis Ulcerosa / Enfermedad de Crohn Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Newborn / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Resultado del Embarazo / Colitis Ulcerosa / Enfermedad de Crohn Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Newborn / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos