Therapeutic application of intrabodies against age-related neurodegenerative disorders.
Curr Pharm Des
; 20(38): 6028-36, 2014.
Article
en En
| MEDLINE
| ID: mdl-24641233
Many neurodegenerative diseases, referred to as misfolding diseases, are characterized by the formation and accumulation of pathological extracellular and intracellular misfolded aggregates. Ageing is considered the major risk factor for neurodegenerative disorders and, due to increase of mean lifespan, the clinical relevance is growing dramatically with a urgent need to find new effective therapeutic approaches. The intracellular antibody technology is a gene-based strategy which exploits the specificity of recombinant antibodies to neutralize or modify the function of intracellular and extracellular target antigens. Intrabodies can potentially recognize all the pathological conformers of a misfolding-prone protein, and therefore they are emerging as therapeutic agents for the treatment of misfolding diseases as well as molecular tools for the understanding of their pathogenesis. Here we focus on the application of intrabodies against two major age-related neurodegenerative disorders, Alzheimer's disease (AD) and Parkinson's disease (PD) and the description of in vivo gene delivery systems available for their potential entering in the clinical setting.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Técnicas de Transferencia de Gen
/
Enfermedades Neurodegenerativas
/
Proteínas de la Membrana
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Pharm Des
Asunto de la revista:
FARMACIA
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Emiratos Árabes Unidos