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Synthesis and pharmacological screening of some novel anti-hypertensive agents possessing 5-Benzylidene-2-(phenylimino)-thiazolidin-4-one ring.
Bhalgat, Chetan M; Darda, Pooja V; Bothara, Kailash G; Bhandari, Shashikant V; Gandhi, Jotsna; Ramesh, B.
Afiliación
  • Bhalgat CM; Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara 571448, Nagamangala (tq), Mandya (dist), Karnataka, India. Electronic address: chetanbhalgat2004@gmail.com.
  • Darda PV; Department of Pharmaceutical Chemistry, SCSSS'S Sitabai Thite College of Pharmacy, Shirur, 412210 Pune, Maharashtra, India. Electronic address: darda.pooja@gmail.com.
  • Bothara KG; Department of Pharmaceutical Chemistry, (PG Wing), A.I.S.S.M.S. College of Pharmacy, Pune 411 001, Maharashtra, India.
  • Bhandari SV; Department of Pharmaceutical Chemistry, (PG Wing), A.I.S.S.M.S. College of Pharmacy, Pune 411 001, Maharashtra, India.
  • Gandhi J; Department of Pharmacognosy, Ashokrao Mane College of Pharmacy, Peth Vadgaon 416 112, Maharashtra, India.
  • Ramesh B; Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara 571448, Nagamangala (tq), Mandya (dist), Karnataka, India.
Eur J Med Chem ; 76: 580-8, 2014 Apr 09.
Article en En | MEDLINE | ID: mdl-24637077
In the present study, fourteen derivatives comprising of 5-benzylidene-2-(phenylimino)-thiazolidin-4-one moiety were synthesized. The structures of synthesized compounds were established by elemental analysis, IR, (1)H NMR, (13)C NMR and mass spectral data and tested for electrocardiographic, antiarrhythmic and antihypertensive activities. Compound 11 was found to be most potent in this series. The pharmacological results suggested that, the antiarrhythmic effects of these compounds were related to their Ca(++) ion channel antagonistic properties, which are believed to be due to the presence of 5-benzilidine-2-(phenylimino)-thiazolidin-4-one moiety. The antihypertensive effect of ß-blocker side chain is enhanced by the presence of less bulky aliphatic and heterocyclic tertiary amines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiazolidinas / Antihipertensivos Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2014 Tipo del documento: Article Pais de publicación: Francia
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiazolidinas / Antihipertensivos Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2014 Tipo del documento: Article Pais de publicación: Francia