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Impact of OSA on biological markers in morbid obesity and metabolic syndrome.
Salord, Neus; Gasa, Mercè; Mayos, Mercedes; Fortuna-Gutierrez, Ana Maria; Montserrat, Josep Maria; Sánchez-de-la-Torre, Manuel; Barceló, Antonia; Barbé, Ferran; Vilarrasa, Núria; Monasterio, Carmen.
Afiliación
  • Salord N; Sleep Unit, Department of Respiratory Medicine, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain ; Section of Respiratory Medicine, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Spain ; Universtitat Autonoma de Barcelona, Department of Medicine, Barcel
  • Gasa M; Sleep Unit, Department of Respiratory Medicine, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain ; Section of Respiratory Medicine, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Spain.
  • Mayos M; Universtitat Autonoma de Barcelona, Department of Medicine, Barcelona, Spain ; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Spain ; Sleep Unit, Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Fortuna-Gutierrez AM; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Spain ; Sleep Unit, Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Montserrat JM; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Spain ; Sleep Unit, Department of Respiratory Medicine, Hospital Clinic de Barcelona, Barcelona, Spain.
  • Sánchez-de-la-Torre M; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Spain ; Respiratory Diseases Research Unit, Hospital Universitari Arnau de Vilanova, IRB Lleida Lleida, Spain.
  • Barceló A; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Spain ; Clinic Analysis Service, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
  • Barbé F; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Spain ; Clinic Analysis Service, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
  • Vilarrasa N; Department of Endocrinology and Nutrition, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain ; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain.
  • Monasterio C; Sleep Unit, Department of Respiratory Medicine, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain ; Section of Respiratory Medicine, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Spain ; Centro de Investigación Biomédica en Red de Enfermedades Respirato
J Clin Sleep Med ; 10(3): 263-70, 2014 Mar 15.
Article en En | MEDLINE | ID: mdl-24634623
BACKGROUND AND OBJECTIVE: There is compelling evidence that obstructive sleep apnoea (OSA) can affect metabolic syndrome (MetS) and cardiovascular risk, but the intermediate mechanisms through which it occurs have not been well defined. We explored the impact of OSA in morbidly obese patients with MetS on adipokines, pro-inflammatory markers, endothelial dysfunction, and atherosclerosis markers. METHODS: We included 52 morbidly obese patients in an observational study matched for age, gender and central obesity in 3 groups (OSA-MetS, Non-OSA-MetS, and Non OSA-non-MetS). Anthropometrical, blood pressure, and fasting blood measurements were obtained the morning after an overnight polysomnography. VEGF, soluble CD40 ligand (sCD40L), TNF-α, IL-6, leptin, adiponectin, and chemerin were determined in serum by ELISA. OSA was defined as apnea/ hypopnea index ≥ 15 and MetS by NCEP-ATP III. RESULTS: Cases and control subjects did not differ in age, BMI, waist circumference, and gender (43 ± 10 years, 46 ± 5 kg/m(2), 128 ± 10 cm, 71% females). The cases had severe OSA with 47 (32-66) events/h, time spent < 90% SpO2 7% (5%-31%). All groups presented similar serum cytokines, adipokines, VEGF, and sCD40L levels. CONCLUSIONS: In a morbidly obese population with established MetS, the presence of OSA did not determine any differences in the studied mediators when matched by central obesity. Morbidly obese NonOSA-NonMetS had a similar inflammatory, adipokine VEGF, and sCD40L profile as those with established MetS, with or without OSA. Obesity itself could overwhelm the effect of sleep apnea and MetS in the studied biomarkers. CITATION: Salord N; Gasa M; Mayos M; Fortuna-Gutierrez AM; Montserrat JM; Sánchez-de-la-Torre M; Barceló A; Barbé F; Vilarrasa N; Monasterio C. Impact of OSA on biological markers in morbid obesity and metabolic syndrome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Apnea Obstructiva del Sueño / Síndrome Metabólico Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: J Clin Sleep Med Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Apnea Obstructiva del Sueño / Síndrome Metabólico Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: J Clin Sleep Med Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos