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Varenicline disrupts prepulse inhibition only in high-inhibitory rats.
Goktalay, Tugba; Buyukuysal, Sema; Uslu, Gulsah; Coskun, Aysin S; Yorgancioglu, Arzu; Kayir, Hakan; Uzbay, Tayfun; Goktalay, Gokhan.
Afiliación
  • Goktalay T; Department of Chest Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
  • Buyukuysal S; Department of Medical Pharmacology, Faculty of Medicine, Uludag University, Bursa, Turkey.
  • Uslu G; Department of Medical Pharmacology, Faculty of Medicine, Uludag University, Bursa, Turkey.
  • Coskun AS; Department of Chest Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
  • Yorgancioglu A; Department of Chest Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
  • Kayir H; Department of Medical Pharmacology, Psychopharmacology Research Unit, Gulhane Military Medical Academy, Ankara, Turkey.
  • Uzbay T; Neuropsychopharmacology Application and Research Center, Uskudar University, Istanbul, Turkey.
  • Goktalay G; Department of Medical Pharmacology, Faculty of Medicine, Uludag University, Bursa, Turkey. Electronic address: goktalay@gmail.com.
Prog Neuropsychopharmacol Biol Psychiatry ; 53: 54-60, 2014 Aug 04.
Article en En | MEDLINE | ID: mdl-24632394
Varenicline, a widely used smoking cessation drug, has partial agonistic activity at α4ß2 nicotinic receptors, and full agonistic activity at α7 nicotinic receptors. Thus it may interact with cognitive processes and may alleviate some of the cognitive disturbances observed in psychotic illnesses such as schizophrenia. We aimed to test the effects of varenicline on sensorimotor gating functioning, which is crucial for normal cognitive processes, especially for the integration of sensory and cognitive information processing and the execution of appropriate motor responses. Prepulse inhibition (PPI) of the acoustic startle reflex was used to test the sensorimotor gating functioning. First, the effects of varenicline and nicotine on rats having high or low baseline PPI levels were evaluated; then, varenicline was applied prior to apomorphine (0.5 mg/kg), and MK-801 (0.15 mg/kg), which are used as comparative models of PPI disruption. Varenicline (0.5-3 mg/kg) did not change PPI when given alone in naïve animals. When rats were selected according to their baseline PPI values, varenicline (1 mg/kg) significantly decreased PPI in high-inhibitory (HI) but not in low-inhibitory (LI) rats. Nicotine (1 mg/kg; tartrate salt) produced a similar activity in LI and HI groups. In combination experiments, varenicline did not reverse either apomorphine or the MK-801-induced disruption of PPI. These results demonstrate that the effects of both varenicline and nicotine on sensorimotor gating are influenced by the baseline PPI levels. Moreover, varenicline has no effect on apomorphine or the MK-801-induced disruption of PPI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinoxalinas / Reflejo de Sobresalto / Benzazepinas / Agonistas Nicotínicos / Inhibición Prepulso Límite: Animals Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2014 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinoxalinas / Reflejo de Sobresalto / Benzazepinas / Agonistas Nicotínicos / Inhibición Prepulso Límite: Animals Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2014 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido