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Role of cardiac sympathetic nerves in blood pressure regulation.
Wehrwein, Erica A; Yoshimoto, Misa; Guzman, Pilar; Shah, Amit; Kreulen, David L; Osborn, John W.
Afiliación
  • Wehrwein EA; Michigan State University, Department of Physiology, East Lansing, MI, United States.
  • Yoshimoto M; University of Minnesota, Department of Integrative Biology and Physiology, Minneapolis, MN, United States.
  • Guzman P; University of Minnesota, Department of Integrative Biology and Physiology, Minneapolis, MN, United States.
  • Shah A; Michigan State University, Department of Physiology, East Lansing, MI, United States.
  • Kreulen DL; Michigan State University, Department of Physiology, East Lansing, MI, United States.
  • Osborn JW; University of Minnesota, Department of Integrative Biology and Physiology, Minneapolis, MN, United States. Electronic address: osbor003@umn.edu.
Auton Neurosci ; 183: 30-5, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24629351
Stellate ganglionectomy (SGx) was used to assess the contribution of cardiac sympathetic nerves to neurogenic hypertension in deoxycorticosterone (DOCA)-salt treated rats. Experiments were conducted in two substrains of Sprague-Dawley (SD) rats since previous studies reported bradycardia in Charles River-SD (CR-SD) rats and tachycardia in SASCO-SD (SA-SD) rats with DOCA treatment suggesting different underlying neural mechanisms. Uninephrectomized male rats underwent SGx or SHAM surgery and were instrumented for telemetric monitoring of mean arterial pressure (MAP) and heart rate (HR). After recovery, 0.9% saline solution and DOCA (50mg) were administered. Baseline MAP (Days 0-5 average) after SGx in CR-SD rats (96±2mmHg; n=7) was not significantly different (p=0.08) than CR-SD SHAM rats (103±3mmHg; n=9); however, there was a significantly lower HR during the baseline period (377±7 vs. 432±7bpm, p<0.05) in SGx rats. In SA-SD rats baseline MAP was not different between SGx and SHAM rats and HR was lower in SGx rats (428±8 vs. 371±5bpm, p<0.05). After DOCA treatment in both substrains, MAP and HR were elevated similarly in SHAM and SGx groups showing minimal impact in both groups of SGx on hypertension development. However, overall MAP in SA-SD SHAM rats reached a significantly higher level (155±10mmHg vs 135±5mmHg, p<0.05) than that observed in CR-SD SHAM rats demonstrating that the magnitude of hypertensive response to DOCA-salt treatment varies between substrains. In conclusion, removal of cardiac sympathetic nerves did not alter the development or maintenance of DOCA-salt hypertension in SD rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ganglio Estrellado / Presión Sanguínea / Hipertensión Límite: Animals Idioma: En Revista: Auton Neurosci Asunto de la revista: NEUROLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ganglio Estrellado / Presión Sanguínea / Hipertensión Límite: Animals Idioma: En Revista: Auton Neurosci Asunto de la revista: NEUROLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos