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NK cell intrinsic regulation of MIP-1α by granzyme M.
Baschuk, N; Wang, N; Watt, S V; Halse, H; House, C; Bird, P I; Strugnell, R; Trapani, J A; Smyth, M J; Andrews, D M.
Afiliación
  • Baschuk N; Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3002, Australia.
  • Wang N; Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia.
  • Watt SV; Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3002, Australia.
  • Halse H; Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3002, Australia.
  • House C; Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3002, Australia.
  • Bird PI; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia.
  • Strugnell R; Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia.
  • Trapani JA; 1] Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3002, Australia [2] Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia [3] Sir Peter MacCallum Department of Oncology, The Univer
  • Smyth MJ; 1] Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3002, Australia [2] Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia [3] Sir Peter MacCallum Department of Oncology, The Univer
  • Andrews DM; 1] Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3002, Australia [2] Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia [3] Sir Peter MacCallum Department of Oncology, The Univer
Cell Death Dis ; 5: e1115, 2014 Mar 13.
Article en En | MEDLINE | ID: mdl-24625974
Granzymes are generally recognized for their capacity to induce various pathways of perforin-dependent target cell death. Within this serine protease family, Granzyme M (GrzM) is unique owing to its preferential expression in innate effectors such as natural killer (NK) cells. During Listeria monocytogenes infection, we observed markedly reduced secretion of macrophage inflammatory protein-1 alpha (MIP-1α) in livers of GrzM-deficient mice, which resulted in significantly impaired NK cell recruitment. Direct stimulation with IL-12 and IL-15 demonstrated that GrzM was required for maximal secretion of active MIP-1α. This effect was not due to reduced protein induction but resulted from heightened intracellular accumulation of MIP-1α, with reduced release. These results demonstrate that GrzM is a critical mediator of innate immunity that can regulate chemotactic networks and has an important role in the initiation of immune responses and pathogen control.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Granzimas / Quimiocina CCL3 / Inmunidad Innata / Listeriosis Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Death Dis Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Granzimas / Quimiocina CCL3 / Inmunidad Innata / Listeriosis Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Death Dis Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido