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After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.
Ding, Jingzhen; Mooers, Blaine H M; Zhang, Zhi; Kale, Justin; Falcone, Domina; McNichol, Jamie; Huang, Bo; Zhang, Xuejun C; Xing, Chengguo; Andrews, David W; Lin, Jialing.
Afiliación
  • Ding J; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126.
  • Mooers BHM; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126.
  • Zhang Z; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126.
  • Kale J; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.
  • Falcone D; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.
  • McNichol J; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.
  • Huang B; Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Zhang XC; Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Xing C; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.
  • Andrews DW; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada; Biological Sciences, Sunnybrook Research Institute and Department of Biochemistry, University of Toronto, Toronto, Ontario M4N 3M5, Canada.
  • Lin J; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126. Electronic address: jialing-lin@ouhsc.edu.
J Biol Chem ; 289(17): 11873-11896, 2014 Apr 25.
Article en En | MEDLINE | ID: mdl-24616095

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoptosis / Proteínas Proto-Oncogénicas c-bcl-2 / Proteína X Asociada a bcl-2 / Proteína bcl-X / Mitocondrias Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoptosis / Proteínas Proto-Oncogénicas c-bcl-2 / Proteína X Asociada a bcl-2 / Proteína bcl-X / Mitocondrias Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos