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Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome.
Kim, Jin Ju; Hwang, Kyu Ri; Choi, Young Min; Moon, Shin Yong; Chae, Soo Jin; Park, Chan Woo; Kim, Hye Ok; Choi, Doo Seok; Kwon, Hyuck Chan; Kang, Byung Moon; Lee, Byung Seok; Cho, Si Hyun; Kim, Tai June; Kim, Tak; Kim, Min Ju; Park, Hyun Young.
Afiliación
  • Kim JJ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea; Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea.
  • Hwang KR; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea; Department of Obstetrics and Gynecology, Seoul Metropolitan Government (SMG)-Seoul National University (SNU) Boramae Medical Center, Seoul, South Korea.
  • Choi YM; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: ymchoi@snu.ac.kr.
  • Moon SY; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea.
  • Chae SJ; Department of Obstetrics and Gynecology, Maria Fertility Hospital, Seoul, South Korea.
  • Park CW; Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea.
  • Kim HO; Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea.
  • Choi DS; Department of Obstetrics and Gynecology, Seoul Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
  • Kwon HC; Department of Obstetrics and Gynecology, Miraewa-heemang Hospital, Seoul, South Korea.
  • Kang BM; Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Lee BS; Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea.
  • Cho SH; Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea.
  • Kim TJ; Department of Obstetrics and Gynecology, Mizmedi Women's Hospital, Seoul, South Korea.
  • Kim T; Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South Korea.
  • Kim MJ; Division of Cardiovascular and Rare Diseases, Korea National Institute of Health, Chungbuk, South Korea.
  • Park HY; Division of Cardiovascular and Rare Diseases, Korea National Institute of Health, Chungbuk, South Korea.
Fertil Steril ; 101(5): 1424-30, 2014 May.
Article en En | MEDLINE | ID: mdl-24613538
OBJECTIVE: To investigate the complete metabolic and phenotypic profiles of a large cohort of untreated, consecutively recruited Korean women with polycystic ovary syndrome (PCOS), for whom a registry for Korean women with PCOS was constructed. DESIGN: Observational study. SETTING: Three infertility clinics and 10 university hospitals. PATIENT(S): Eight hundred sixty-five women with PCOS were recruited using the Rotterdam criteria. INTERVENTION(S): Standardized evaluation protocol and web-based case report form. MAIN OUTCOME MEASURE(S): Metabolic and phenotypic profiles. RESULT(S): The subjects with PCOS mainly consisted of young and nonobese women. The most problematic subjective symptom was menstrual disturbance or infertility, and, on average, the patients seemed to menstruate every 2 months. PCO morphology was observed in 96.5% of the patients. Although few women visited hospitals owing to HA symptoms alone, hirsutism was observed in one-third of the patients (33.9%) and half (47.4%) of the patients had biochemical HA. About one-fifth (20.1%) of the patients had generalized obesity, and one-third (33.2%) had central obesity. Prevalence of dyslipidemia, diabetes, hypertension, and metabolic syndrome were 35.7%, 3.5%, 4.0%, and 13.7%, respectively. Prevalence of prediabetes was 20.8%, and a substantial proportion of additional subjects with normal fasting plasma glucose or oral glucose tolerance tests were identified as having prediabetes by hemoglobin A1C testing. CONCLUSION(S): Our well-defined cohort provided comprehensive estimates of the features of metabolic and phenotypic profiles related to PCOS in Korean women. Further longitudinal follow-up studies are needed to investigate the changes in phenotypic and metabolic markers in this PCOS cohort.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenotipo / Síndrome del Ovario Poliquístico / Pueblo Asiatico / Metaboloma Tipo de estudio: Clinical_trials / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans País/Región como asunto: Asia Idioma: En Revista: Fertil Steril Año: 2014 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenotipo / Síndrome del Ovario Poliquístico / Pueblo Asiatico / Metaboloma Tipo de estudio: Clinical_trials / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans País/Región como asunto: Asia Idioma: En Revista: Fertil Steril Año: 2014 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos