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Identification of a B cell-dependent subpopulation of multiple sclerosis by measurements of brain-reactive B cells in the blood.
Kuerten, Stefanie; Pommerschein, Giovanna; Barth, Stefanie K; Hohmann, Christopher; Milles, Bianca; Sammer, Fabian W; Duffy, Cathrina E; Wunsch, Marie; Rovituso, Damiano M; Schroeter, Michael; Addicks, Klaus; Kaiser, Claudia C; Lehmann, Paul V.
Afiliación
  • Kuerten S; Department of Anatomy and Cell Biology, University of Wuerzburg, Germany. Electronic address: stefanie.kuerten@uni-wuerzburg.de.
  • Pommerschein G; Department of Anatomy I, University of Cologne, Germany.
  • Barth SK; Department of Anatomy I, University of Cologne, Germany.
  • Hohmann C; Department of Anatomy I, University of Cologne, Germany.
  • Milles B; Department of Anatomy I, University of Cologne, Germany.
  • Sammer FW; Department of Anatomy I, University of Cologne, Germany.
  • Duffy CE; Department of Anatomy I, University of Cologne, Germany.
  • Wunsch M; Department of Anatomy and Cell Biology, University of Wuerzburg, Germany.
  • Rovituso DM; Department of Anatomy and Cell Biology, University of Wuerzburg, Germany.
  • Schroeter M; Department of Neurology, University of Cologne, Germany.
  • Addicks K; Department of Anatomy I, University of Cologne, Germany.
  • Kaiser CC; Department of Neurology, University of Cologne, Germany.
  • Lehmann PV; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Cellular Technology Limited, Shaker Heights, OH, USA.
Clin Immunol ; 152(1-2): 20-4, 2014.
Article en En | MEDLINE | ID: mdl-24607792
B cells are increasingly coming into play in the pathogenesis of multiple sclerosis (MS). Here, we screened peripheral blood mononuclear cells (PBMC) from patients with clinically isolated syndrome (CIS), MS, other non-inflammatory neurological, inflammatory neurological or autoimmune diseases, and healthy donors for their B cell reactivity to CNS antigen using the enzyme-linked immunospot technique (ELISPOT) after 96 h of polyclonal stimulation. Our data show that nine of 15 patients with CIS (60.0%) and 53 of 67 patients with definite MS (79.1%) displayed CNS-reactive B cells, compared to none of the control donors. The presence of CNS-reactive B cells in the blood of the majority of patients with MS or at risk to develop MS along with their absence in control subjects suggests that they might be indicative of a B cell-dependent subpopulation of the disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Sistema Nervioso Central / Enfermedades Desmielinizantes / Esclerosis Múltiple Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Sistema Nervioso Central / Enfermedades Desmielinizantes / Esclerosis Múltiple Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos